New treatments are urgently needed to combat the increasing number of dengue fever
cases in endemic countries as well as amongst a large number of travellers from non-endemic …

The replication of flaviviruses requires the correct processing of their polyprotein by the viral
NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of …

Dengue fever is an emerging arboviral disease for which no vaccine or antiviral treatment
exists and that causes thousands of fatalities each year. To develop an in vivo test system for …

Zika virus (ZIKV) remains a potentially significant public health concern because it can
cause teratogenic effects, such as microcephaly in newborns and neurological disease, like …

The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein. …

Dengue virus is the most widespread geographically of the arboviruses and a major public
health threat in the tropics and subtropics. Scientific advances in recent years have provided …

Self-replicating, non-infectious flavivirus subgenomic replicons have been broadly used in
the studies of trans-complementation, adaptive mutation, viral assembly and packaging in …

Continued geographic expansion of dengue viruses and their mosquito vectors has seen
the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (DF/DHF) …

Dengue fever, a neglected emerging disease for which no vaccine or antiviral agents exist
at present, is caused by dengue virus, a member of the Flavivirus genus, which includes …

Type I interferon (IFN–I) evasion by Dengue virus (DENV) is key in DENV pathogenesis. The
non-structural protein 5 (NS5) antagonizes IFN-I response through the degradation of the …