Targeted in vivo labeling of receptors for vascular endothelial growth factor: approach to identification of ischemic tissue

…, JA Abraham, AL Klibanov, SR Woulfe… - Circulation, 2003 - Am Heart Assoc
Background— A method for identifying tissue experiencing hypoxic stress due to atherosclerotic
vascular disease would be clinically useful. Vascular endothelial growth factor-121 (…

Versatile methods for the synthesis of differentially functionalized pentaerythritol amine derivatives

…, WL Neumann, MM Rogic, SR Woulfe - The Journal of Organic …, 1990 - ACS Publications
8 (aminomethyl) ethane (TAME)(1) has been used as a tridentate ligand itself or as a starting
material for the synthesis of more complex hexadentate ligand systems. 2 Its interesting …

[PDF][PDF] Human biodistribution, dosimetry and clinical use of technetium (III)-99m-Q12

…, K Deutsch, M Marmion, SR Woulfe… - Journal of Nuclear …, 1994 - Soc Nuclear Med
(2.2% Injecteddoseat 1 hr postinjectionunderrestingcondi tions) and no detectable myocard@
washout or redistributionup to 5 hr posbnjec@ on. The t@ OdiStdbUtIOnis characte&ed …

The synthesis of substituted [[3 (S)-(acylamino)-2-oxo-1-azetidinyl] thio] acetic acids

SR Woulfe, MJ Miller - The Journal of Organic Chemistry, 1986 - ACS Publications
I the tert-butyldimethylsilyl-protected11 threonine 8 to the corresponding acid chloride (oxalyl
chloride/DMF) 12 fol-lowed by reaction with triphenylmethanesufenamide 9b provided the …

Synthesis and biological activity of substituted [[3 (S)-(acylamino)-2-oxo-1-azetidinyl] oxy] acetic acids. A new class of heteroatom-activated. beta.-lactam antibiotics

SR Woulfe, MJ Miller - Journal of medicinal chemistry, 1985 - ACS Publications
The synthesis of substituted [[3 (S)-(acylamino)-2-oxo-1-azetidinyl] oxy] acetic acids (1) is
described. 3-[(Carbobenzyloxy) amino]-jV-hydroxy-2-azetidinones (13a, b), prepared from …

Heteroatom-activated. beta.-lactam antibiotics: considerations of differences in the biological activity of [[3 (S)-(acylamino)-2-oxo-1-azetidinyl] oxy] acetic acids …

…, MJ Miller, CE Pasini, SR Woulfe - Journal of medicinal …, 1987 - ACS Publications
The considerable antibacterial activity of [[3 (S)-(acylamino)-2-oxo-l-azetidinyl] oxy] acetic
acids (oxamazins) in contrast to the lack of activity of the corresponding sulfur analogues (…

Preparation and characterization of technetium complexes with Schiff base and phosphine coordination. 1. Complexes of technetium-99g and-99m with substituted …

ME Marmion, SR Woulfe, WL Neumann… - Nuclear medicine and …, 1999 - Elsevier
A series of 23 technetium(III) complexes of the type [TcL(PR 3 ) 2 ]+, where L represents a
tetradentate Schiff base ligand in the equatorial plane and PR 3 represents the axial …

Heteroatom activated β-lactam antibiotics: Synthesis of biologically active substituted N-oxy-3-amino-2-azetidinones (oxamazins)

SR Woulfe, MJ Miller - Tetrahedron letters, 1984 - Elsevier
Representatives of a new class of oxygen activated β-lactams (oxamazins) have been
synthesized from N-hydroxy-3-amino-2-azetidinones. The oxamazins show significant …

Synthesis and preliminary evaluation of MP‐2269: a novel, nonaromatic small‐molecule blood‐pool MR contrast agent

…, JP Haar Jr, DB Miller, SR Woulfe… - Magnetic resonance …, 1998 - Wiley Online Library
A nonaromatic, small‐molecule, gadolinium(3+)‐chelate code named MP‐2269 was synthesized
and evaluated in animals as a potential MR contrast agent for blood pool. The ligand of …

Efficient N-sulfenylation of 2-azetidinones using S-substituted thiophthalimides

SR Woulfe, H Iwagami, MJ Miller - Tetrahedron letters, 1985 - Elsevier
Reaction of N-unsubstituted β-lactams with various S-substituted thiophthalimides provides
an efficient route to the corresponding N-thio-2-azetidinones.