Kappa opioid receptors and their endogenous neuropeptide ligand, dynorphin A, are densely
localized in limbic and cortical areas comprising the brain reward system, and appear to …

Kappa-opioid receptors (KOR) are believed to be involved in the pathophysiology of depression,
anxiety disorders, drug abuse, and alcoholism. To date, only 1 tracer, the KOR agonist …

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and
selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster …

• Twelve female patients with necrobiosis lipoidica diabeticorum (six with diabetes and six
without) had a 5-mm punch biopsy of the skin lesion performed. The tissue was processed for …

Superficial granulomatous pyoderma is a form of pyoderma gangrenosum characterized by
superficial ulceration and a chronic course. Histopathologic examination shows a …

As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and
3 (mGlu 2/3 ) receptors, we have incorporated substitution at the C3 and C4 positions of the (…

An unusual edematous and indurated erythema developed in four patients with breast
carcinoma 1 to 6 months after conservative surgical treatment and irradiation. The radiation …

Here we report on novel, potent 3,3-dimethyl substituted N-aryl piperidine inhibitors of
microsomal prostaglandin E synthases-1(mPGES-1). Example 14 potently inhibited PGE 2 …

Nine patients with plaquelike cutaneous mucinosis, including the three described originally
in 1960, are presented. The clinical manifestations of asymptomatic, persistent, erythematous…

We describe a novel class of acidic mPGES-1 inhibitors with nanomolar enzymatic and human
whole blood (HWB) potency. Rational design in conjunction with structure-based design …