The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

While a potential causal factor in Alzheimer’s disease (AD), brain insulin resistance has not
been demonstrated directly in that disorder. We provide such a demonstration here by …

Insulin resistance and other features of the metabolic syndrome are increasingly recognized
for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed …

The distribution of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) was mapped in
39 cortical areas of 11 brains of patients with Alzheimer's disease (AD). Whole hemisphere …

Positron emission tomography was used to evaluate the regional distribution of cerebral
glucose metabolism in 61 healthy adults at rest. Although the profile of metabolic activity was …

Background Neuroanatomic studies of schizophrenia have reported temporolimbic abnormalities.
Most magnetic resonance imaging studies have evaluated small samples of primarily …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Context Social isolation in old age has been associated with risk of developing dementia, but
the risk associated with perceived isolation, or loneliness, is not well understood. Objective …

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and type …