The integrin α4β1 is involved in mediating exfiltration of leukocytes from the vasculature. It
interacts with a number of proteins up-regulated during the inflammatory response including …

The integrins α v β 1 , α v β 5 , α v β 6 and α v β 8 have all recently been shown to interact
with the RGD motif of the latency-associated peptide (LAPβ 1 ) of transforming growth factor β …

There is a requirement for efficacious and safe medicines to treat diseases with high unmet
need. The resurgence in αv‐RGD integrin inhibitor drug discovery is poised to contribute to …

Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of
idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung …

The extracellular matrix protein osteopontin (OPN) interacts with a number of integrins,
namely αvβ1, αvβ3, αvβ5, α9β1, α8β1, and α4β1. We have investigated the interaction of α5β1 …

The osteopontin SVVYGLR motif binds the integrins α 4 β 1 and α 9 β 1 . We show that α 4 β
7 also interacts with this motif and that an SVVYGLR-OH peptide antagonises the α 4 β 7 …

Members of the Rho family of small G proteins transduce signals from plasma-membrane
receptors and control cell adhesion, motility and shape by actin cytoskeleton formation 1–4 . …

Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints,
cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought …

A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity
and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding …

purpose. To determine whether SB-267268, a nonpeptidic antagonist of the α v β 3 and α v
β 5 integrins, attenuates angiogenesis in a murine model of retinopathy of prematurity (ROP) …