Over the past few years, evidence has accumulated that the human brain is an insulin-sensitive
organ. Insulin regulates activity in a limited number of specific brain areas that are …

Obesity is a key risk factor for the development of insulin resistance, Type 2 diabetes and
associated diseases; thus, it has become a major public health concern. In this context, a …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic effects, …

Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in
brain insulin action represent a possible link between metabolic and cognitive health. Current …

Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction.
Intranasal insulin is a promising tool to investigate central insulin action in humans. We …

The use of neuroimaging tools, especially functional magnetic resonance imaging, in
nutritional research has increased substantially over the past 2 decades. Neuroimaging is a …

Brain insulin action regulates eating behavior and energy fluxes throughout the body. However,
numerous people are brain insulin resistant. How brain insulin responsiveness affects …

Aims To conduct a review in order to assess the safety of intranasal human insulin in clinical
studies as well as the temporal stability of nasal insulin sprays. Material and methods An …

In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated
chronic diseases, is generated by excessive eating. For a better understanding of eating …

Objective Activity in the dopaminergic pathways of the brain is highly sensitive to body weight
and metabolic states. Animal studies show that dopamine neurons are important targets for …