N,N,N-Trimethylated chitosan (TMC) with varying degree of quaternization (DQ) is currently
being investigated in mucosal drug, vaccine and in gene delivery. However, besides N-…

To achieve highly effective glucocorticoid targeting for rheumatoid arthritis therapy, novel,
polymerizable and hydrolytically cleavable dexamethasone (DEX) derivatives were covalently …

A novel four-step method is presented to synthesize partially thiolated trimethylated chitosan
(TMC) with a tailorable degree of quaternization and thiolation. First, chitosan was partially …

The potential of receptor-mediated fluorescence-based image-guided surgery tracers is
generally linked to the near-infrared emission profile and good-manufacturing-production …

… Steffen van der Wal a 1 , Joeri Kuil b c 1 , A. Rob PM Valentijn b , Fijs WB van Leeuwen a d
… in dye 11 was envisioned to decrease Van der Waal's forces between the reduced aromatic …

… Slootweg and Steffen van der Wal contributed equally to this work. … Steffen van der Wal
- Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, …

Synthetic mimics of discontinuous epitopes may have a wide range of potential applications,
including synthetic vaccines and inhibition of protein–protein interactions. However, …

Newly formed tumor vasculature has proven to be an effective target for tumor therapy. A
strategy to attack this angiogenic tumor vasculature is to initiate local blood vessel congestion …

The successful use of mRNA vaccines enabled and accelerated the development of several
new vaccine candidates and therapeutics based on the delivery of mRNA. In this study, we …

We report an efficient strategy to conjugate methacrylamide moieties to the lysine units of
lysozyme for co-polymerization and subsequent triggered release from hydrogels. Two novel …