Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

M Fuhrmann, T Bittner, CKE Jung, S Burgold… - Nature …, 2010 - nature.com
Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease
by phagocytosing amyloid-β. Two-photon in vivo imaging of neuron loss in the intact brain of …

Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis

…, M Fuhrmann, L Von Baumgarten, S Burgold… - Glia, 2009 - Wiley Online Library
Infiltration of cancer cells into normal tissue is a hallmark of malignant gliomas and compromises
treatment options. A lack of appropriate models limits the study of this invasion in vivo, …

[HTML][HTML] Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice

C Schön, NA Hoffmann, SM Ochs, S Burgold, S Filser… - PloS one, 2012 - journals.plos.org
Tauopathies are widespread neurodegenerative disorders characterised by the intracellular
accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological …

Bevacizumab has differential and dose-dependent effects on glioma blood vessels and tumor cells

…, A Tirniceru, Y Kienast, S Grau, S Burgold… - Clinical Cancer …, 2011 - AACR
Purpose: Bevacizumab targets VEGF-A and has proved beneficial in glioma patients, improving
clinical symptoms by the reduction of tumor edema. However, it remains controversial …

[HTML][HTML] Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice

T Bittner, M Fuhrmann, S Burgold, SM Ochs… - PloS one, 2010 - journals.plos.org
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β
(Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss. By …

γ-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway

T Bittner, M Fuhrmann, S Burgold… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease (AD) represents the most common age-related neurodegenerative
disorder. It is characterized by the invariant accumulation of the β-amyloid peptide (Aβ), which …

[HTML][HTML] Amyloid plaque formation precedes dendritic spine loss

T Bittner, S Burgold, MM Dorostkar, M Fuhrmann… - Acta …, 2012 - Springer
Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s
disease. While numerous studies have described dendritic spine loss in proximity to …

Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET

A Rominger, M Brendel, S Burgold… - Journal of Nuclear …, 2013 - Soc Nuclear Med
The progression of β-amyloid deposition in the brains of mice overexpressing Swedish
mutant β-amyloid precursor protein (APP-Swe), a model of Alzheimer disease (AD), was …

[HTML][HTML] In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks

S Burgold, T Bittner, MM Dorostkar, D Kieser… - Acta …, 2011 - Springer
The kinetics of amyloid plaque formation and growth as one of the characteristic hallmarks
of Alzheimer’s disease (AD) are fundamental issues in AD research. Especially the question …

Bis (arylvinyl) pyrazines,-pyrimidines, and-pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models

…, C Voss, S Bauer, C Schön, S Burgold… - Journal of Medicinal …, 2012 - ACS Publications
The in vivo diagnosis of Alzheimer’s disease (AD) is of high socioeconomic interest and
remains a demanding field of research. The biopathological hallmarks of the disease are …