BackgroundRepetitive transcranial magnetic stimulation (rTMS) has been proposed as a new
treatment option for depression. Previous studies were performed with low sample sizes in …

Objective To assess patterns and impact of small nerve fiber dysfunction and pathology in
patients with fibromyalgia syndrome (FMS). Methods One hundred seventeen women with …

Objectives: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations
in blood, pharmacological interpretation and treatment guidance. TDM introduces a …

Advanced stages of Parkinson’s disease (advPD) still impose a challenge in terms of
classification and related stage-adapted treatment recommendations. Previous concepts that …

Recent neuroimaging studies have suggested that a hyperactivity of the frontal-striate
neuronal circuits, including the orbitofrontal cortex and the basal ganglia, mediates the …

Rationale In psychiatric clinical practice, there is a need to identify psychotropic drugs whose
metabolisms are prone to be altered with increased inflammatory activity in an individual …

Background Pharmacogenetics (PGx), especially in regard to CYP2D6, is gaining more
importance in routine clinical settings. Including phenoconversion effects (PC) in result …

Introduction Pharmacogenetic testing is proposed to minimize adverse effects when considered
in combination with pharmacological knowledge of the drug. As yet, limited studies in …

Background Sertraline is a selective serotonin reuptake inhibitor with specific indications in
child and adolescent psychiatry. Notwithstanding its frequent use and clinical benefits, the …

Introduction Despite the growing evidence base for psychotropic drug treatment in pediatric
patients, knowledge about the benefit-risk ratio in clinical practice remains limited. The ‘…