ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

…, E Kremmer, S Roßner, SF Lichtenthaler - The EMBO …, 2010 - embopress.org
The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity
called α‐secretase. This is considered an important mechanism preventing the generation …

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

…, N Katzmarski, S Krasemann, SF Lichtenthaler… - Nature …, 2019 - nature.com
Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated
with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding …

[PDF][PDF] Phosphorylation of the translation initiation factor eIF2α increases BACE1 levels and promotes amyloidogenesis

…, B Hitt, LA Bembinster, S Lammich, SF Lichtenthaler… - Neuron, 2008 - cell.com
β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid (Aβ) production,
is elevated in Alzheimer's disease (AD). Here, we show that energy deprivation induces …

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

…, PC Wong, SF Lichtenthaler - Journal of …, 2014 - Wiley Online Library
The β‐site APP cleaving enzymes 1 and 2 ( BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein ( APP ). BACE 1 …

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

…, C Haass, S Roßner, S Bräse, SF Lichtenthaler - The EMBO …, 2012 - embopress.org
Cell surface proteolysis is essential for communication between cells and results in the
shedding of membrane‐protein ectodomains. However, physiological substrates of the …

[HTML][HTML] γ-Secretase directly sheds the survival receptor BCMA from plasma cells

…, H Wekerle, R Hohlfeld, SF Lichtenthaler… - Nature …, 2015 - nature.com
Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-bound
receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ-…

[HTML][HTML] The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1

SF Lichtenthaler, D Dominguez, GG Westmeyer… - Journal of Biological …, 2003 - ASBMB
The aspartyl protease BACE1 cleaves the amyloid precursor protein and the sialyltransferase
ST6Gal I and is important in the pathogenesis of Alzheimer's disease. The normal function …

Regulated intramembrane proteolysis–lessons from amyloid precursor protein processing

SF Lichtenthaler, C Haass… - Journal of …, 2011 - Wiley Online Library
… A more detailed description of α-secretase in APP cleavage and Aβ generation is found
in a recent review (Lichtenthaler 2011). The APP ectodomain released upon α-secretase …

Mechanism of the cleavage specificity of Alzheimer's disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the …

SF Lichtenthaler, R Wang, H Grimm… - Proceedings of the …, 1999 - National Acad Sciences
Proteolytic processing of the amyloid precursor protein by β-secretase yields A4CT (C99),
which is cleaved further by the as yet unknown γ-secretase, yielding the β-amyloid (Aβ) …

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

SF Lichtenthaler, MK Lemberg, R Fluhrer - The EMBO journal, 2018 - embopress.org
Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐translational
modification that controls levels and function of hundreds of membrane proteins. …