Objective: To investigate the prevalence and nature of cognitive changes associated with
sporadic amyotrophic lateral sclerosis (ALS) using a large scale study. Methods: Consecutive …

Over 1200 patients with motor neuron disease have been carefully diagnosed, followed, and
included in a detailed database delineating characteristics of the disease. Of these patients…

The causes of amyotrophic lateral sclerosis, Parkinson disease, and Alzheimer disease are
unknown. Furthermore, treatment for two of these conditions is almost totally lacking. The …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls…

The most common inherited form of amyotrophic lateral sclerosis (ALS), a neurodegenerative
disease affecting adult motoneurons, is caused by dominant mutations in the ubiquitously …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

Background Mutations in SOD1 cause 13% of familial amyotrophic lateral sclerosis. In the
SOD1 Gly93Ala rat model of amyotrophic lateral sclerosis, the antisense oligonucleotide ISIS …

Dendritic cells are potent antigen‐presenting cells that initiate and amplify immune responses.
To determine whether dendritic cells participate in inflammatory reactions in amyotrophic …

Two mutant mice with deficient myelination are described. Quaking is a new autosomal
recessive mutant mouse with marked tremor of the hindquarters. The mice eat, swim, breed, and …

NR4A2, encoding a member of nuclear receptor superfamily 1, is essential for the
differentiation of the nigral dopaminergic neurons 2, 3, 4. To determine whether NR4A2 is a …