[HTML][HTML] The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers
A Paul, S Paul - Frontiers in bioscience (Landmark edition), 2014 - ncbi.nlm.nih.gov
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of
genomic integrity. Inherited mutations in these genes are associated with the development …
genomic integrity. Inherited mutations in these genes are associated with the development …
[HTML][HTML] Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation
Mammalian reproduction is critically dependent on the trophoblast cell lineage, which
assures proper establishment of maternal-fetal interactions during pregnancy. Specification of …
assures proper establishment of maternal-fetal interactions during pregnancy. Specification of …
TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss
…, VA French, S Gunewardena, S Paul - Proceedings of the …, 2020 - National Acad Sciences
Early pregnancy loss affects ∼15% of all implantation-confirmed human conceptions.
However, evolutionarily conserved molecular mechanisms that regulate self-renewal of …
However, evolutionarily conserved molecular mechanisms that regulate self-renewal of …
Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription
…, A Ganguly, J Milano-Foster, A Paul… - …, 2018 - journals.biologists.com
Early mammalian development is crucially dependent on the establishment of oxidative
energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE cells …
energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE cells …
[HTML][HTML] GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression
During early mammalian development, genesis of the first two cell lineages, inner cell mass
(ICM) and trophectoderm (TE), is dependent upon functions of key transcription factors that …
(ICM) and trophectoderm (TE), is dependent upon functions of key transcription factors that …
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
In the preimplantation mouse embryo, TEAD4 is critical to establishing the trophectoderm (TE)-specific
transcriptional program and segregating TE from the inner cell mass (ICM). …
transcriptional program and segregating TE from the inner cell mass (ICM). …
Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian …
GATA transcription factors are implicated in establishing cell fate during mammalian development.
In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic …
In early mammalian embryos, GATA3 is selectively expressed in the extraembryonic …
Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage
Cell fate decisions are fundamental to the development of multicellular organisms. In mammals
the first cell fate decision involves segregation of the pluripotent inner cell mass and the …
the first cell fate decision involves segregation of the pluripotent inner cell mass and the …
Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance
The intricate molecular mechanisms that regulate ESC pluripotency are incompletely
understood. Prior research indicated that activation of the Janus kinase–signal transducer and …
understood. Prior research indicated that activation of the Janus kinase–signal transducer and …
Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation
Healthy progression of human pregnancy relies on cytotrophoblast (CTB) progenitor self-renewal
and its differentiation toward multinucleated syncytiotrophoblasts (STBs) and invasive …
and its differentiation toward multinucleated syncytiotrophoblasts (STBs) and invasive …