Immunotherapy of cancer in 2012
…, H Zarour, P Kalinski, S Ferrone - CA: a cancer journal …, 2012 - Wiley Online Library
The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology. These …
improved understanding of the underlying principles of tumor biology and immunology. These …
Escape of human solid tumors from T–cell recognition: Molecular mechanisms and functional significance
FM Marincola, EM Jaffee, DJ Hicklin, S Ferrone - Advances in immunology, 1999 - Elsevier
Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
may be associated with the appearance of tumor associated antigens (TAA). Decades of …
[PDF][PDF] Antitumor responses in the absence of toxicity in solid tumors by targeting B7-H3 via chimeric antigen receptor T cells
…, SG Herrera, Y Xu, C Sun, Y Chen, X Ma, CR Ferrone… - Cancer cell, 2019 - cell.com
The high expression across multiple tumor types and restricted expression in normal tissues
make B7-H3 an attractive target for immunotherapy. We generated chimeric antigen …
make B7-H3 an attractive target for immunotherapy. We generated chimeric antigen …
[HTML][HTML] Tumor antigen–targeted, monoclonal antibody–based immunotherapy: clinical response, cellular immunity, and immunoescape
Purpose Tumor antigen (TA)–targeted monoclonal antibodies (mAb), rituximab, trastuzumab,
and cetuximab, are clinically effective for some advanced malignancies, especially in …
and cetuximab, are clinically effective for some advanced malignancies, especially in …
Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance
S Ferrone, FM Marincola - Immunology today, 1995 - cell.com
Malignant transformation of melanocytes may be associated with changes in the expression
of major histocompatibility complex (MHCJ HLA class I antigens. Interest in the …
of major histocompatibility complex (MHCJ HLA class I antigens. Interest in the …
Soluble HLA‐A,‐B,‐C and ‐G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
…, A Poggi, G Filaci, F Indiveri, S Ferrone… - European journal of …, 2003 - Wiley Online Library
There is convincing evidence that soluble HLA‐A,‐B,‐C (sHLA‐A,‐B,‐C) and soluble HLA‐G
(sHLA‐G) antigens can induce apoptosis in CD8 + activated T cells although there is …
(sHLA‐G) antigens can induce apoptosis in CD8 + activated T cells although there is …
Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility …
…, R Biassoni, R Conte, M Kubin, D Cosman, S Ferrone… - Cancer research, 2002 - AACR
NKG2D, together with NKp46 and NKp30, represents a major triggering receptor involved in
the induction of cytotoxicity by both resting and activated human natural killer cells. In this …
the induction of cytotoxicity by both resting and activated human natural killer cells. In this …
Antigen-processing machinery breakdown and tumor growth
B Seliger, MJ Maeurer, S Ferrone - Immunology today, 2000 - cell.com
Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery
(APM) have been described in tumors of different histology. Murine data suggest that …
(APM) have been described in tumors of different histology. Murine data suggest that …
Impaired HLA class I antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer
…, J Agorreta, LM Montuenga, R Lifton, S Ferrone… - Cancer discovery, 2017 - AACR
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICI) are poorly
understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate …
understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate …
HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story
DJ Hicklin, FM Marincola, S Ferrone - Molecular medicine today, 1999 - cell.com
Human leukocyte antigen (HLA) class I molecule downregulation occurs frequently in many
cancers, and this abnormality might adversely affect the clinical course of cancer and the …
cancers, and this abnormality might adversely affect the clinical course of cancer and the …