Brain imaging of Alzheimer dementia patients and elderly controls with 18F-MK-6240, a PET tracer targeting neurofibrillary tangles
…, NF Telan-Choing, K Riffel, S Celen… - Journal of Nuclear …, 2019 - Soc Nuclear Med
18 F-MK-6240 ( 18 F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine)
is a highly selective, subnanomolar-affinity PET tracer for imaging neurofibrillary tangles (…
is a highly selective, subnanomolar-affinity PET tracer for imaging neurofibrillary tangles (…
Preclinical evaluation of a P2X7 receptor–selective radiotracer: PET studies in a rat model with local overexpression of the human P2X7 receptor and in nonhuman …
D Ory, S Celen, R Gijsbers… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The P2X7 receptor (P2X7R) orchestrates neuroinflammation, and this is the basis for an
increased interest in the development of antagonists inhibiting P2X7R function in the brain. This …
increased interest in the development of antagonists inhibiting P2X7R function in the brain. This …
18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability, and occupancy of the P2X7 antagonist …
…, D Van Weehaeghe, K Serdons, S Celen… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The P2X7 receptor (P2X7R) is an adenosine triphosphate–gated ion channel that is
predominantly expressed on microglial cells in the central nervous system. We report the clinical …
predominantly expressed on microglial cells in the central nervous system. We report the clinical …
TSPO versus P2X7 as a target for neuroinflammation: an in vitro and in vivo study
…, J De Vocht, M Koole, B Attili, S Celen… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R)
is a promising target for neuroinflammation. The objective of this study was to …
is a promising target for neuroinflammation. The objective of this study was to …
Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission …
…, H Lavreysen, AA Trabanco, S Celen… - Journal of medicinal …, 2012 - ACS Publications
The synthesis and in vitro and in vivo evaluation of a new series of 7-(phenylpiperidinyl)-1,2,4-triazolo[4,3-a]pyridines,
which were conveniently radiolabeled with carbon-11, as …
which were conveniently radiolabeled with carbon-11, as …
PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide
…, T Dresselaers, W Gsell, A Postnov, S Celen… - Nuclear medicine and …, 2015 - Elsevier
Objective The goal of this study was to measure functional and structural aspects of local
neuroinflammation induced by intracerebral injection of lipopolysaccharide (LPS) in rats using …
neuroinflammation induced by intracerebral injection of lipopolysaccharide (LPS) in rats using …
Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: a multiple‐ascending dose and a positron emission tomography study in healthy volunteers
…, JA Palmer, S Rassnick, S Celen… - Clinical and …, 2018 - Wiley Online Library
Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is
hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The …
hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The …
PET radioligands for in vivo visualization of neuroinflammation
D Ory, S Celen, A Verbruggen… - Current pharmaceutical …, 2014 - ingentaconnect.com
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role
in neurodegenerative disorders. The microglia which make up the innate immune system …
in neurodegenerative disorders. The microglia which make up the innate immune system …
Translation of HDAC6 PET Imaging Using [18F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates
S Celen, J Rokka, TM Gilbert, M Koole… - ACS chemical …, 2020 - ACS Publications
Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse
cellular processes such as intracellular transport and protein quality control. Inhibition of …
cellular processes such as intracellular transport and protein quality control. Inhibition of …
Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain
S Celen, M Koole, M De Angelis, I Sannen… - Journal of nuclear …, 2010 - Soc Nuclear Med
Phosphodiesterases are enzymes that inactivate the intracellular second messengers 3′,5′-cyclic
adenosine-monophosphate and/or cyclic guanosine-monophosphate. Of all 11 …
adenosine-monophosphate and/or cyclic guanosine-monophosphate. Of all 11 …