Near complete reabsorption of filtered amino acids is a main specialized transport function
of the kidney proximal tubule. This evolutionary conserved task is carried out by a subset of …

ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a
broad tissue distribution with highest expression levels at the brush border membrane (BBM) …

Malnutrition affects up to one billion people in the world and is a major cause of mortality 1 ,
2 . In many cases, malnutrition is associated with diarrhoea and intestinal inflammation, …

Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane
of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this …

BACKGROUND & AIMS: Hartnup amino acid transporter B 0 AT1 (SLC6A19) is the major
luminal sodium-dependent neutral amino acid transporter of small intestine and kidney …

Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system
involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (…

The mineralocorticoid hormone aldosterone controls sodium reabsorption and BP largely
by regulating the cell-surface expression and function of the epithelial sodium channel (ENaC) …

The Btransport system mediates the Na + -driven uptake of a broad range of neutral amino
acids into epithelial cells of small intestine and kidney proximal tubule. A corresponding …

Mutations in the main intestinal and kidney luminal neutral amino acid transporter B 0 AT1 (Slc6a19)
lead to Hartnup disorder, a condition that is characterized by neutral aminoaciduria …

System L amino acid transport is increased in various types of cancer. The tracer 123 I-2-iodotyrosine
(2IT), which is accumulated via system L, could thus serve to allow visualization of …