User profiles for Siddesh V Hartimath
 | SV HartimathINSTITUTE OF BIOENGINEERING AND BIOIMAGING (IBB) Verified email at ibb.a-star.edu.sg Cited by 482 |
[HTML][HTML] Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury
Malaria-associated acute respiratory distress syndrome (ARDS) and acute lung injury (ALI)
are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms …
are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms …
[HTML][HTML] Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans
…, J Peng, LJ Tan, SV Hartimath… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated
bile acids (BAs) that are associated with insulin resistance in humans. …
bile acids (BAs) that are associated with insulin resistance in humans. …
[HTML][HTML] Granzyme B PET imaging of combined chemotherapy and immune checkpoint inhibitor therapy in colon cancer
JL Goggi, SV Hartimath, TY Xuan, S Khanapur… - Molecular Imaging and …, 2021 - Springer
Purpose Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU),
that enhance the immune system, are being assessed as strategies to improve durable …
that enhance the immune system, are being assessed as strategies to improve durable …
111In- and 225Ac-Labeled Cixutumumab for Imaging and α-Particle Radiotherapy of IGF-1R Positive Triple-Negative Breast Cancer
…, E Alizadeh, W Bernhard, SV Hartimath… - Molecular …, 2019 - ACS Publications
Insulin growth factor receptor (IGF-1R) is overexpressed in many cancers of epithelial origin,
where it confers enhanced proliferation and resistance to therapies targeted at other …
where it confers enhanced proliferation and resistance to therapies targeted at other …
Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya
…, SN Amrun, KWW Teng, SV Hartimath… - EMBO Molecular …, 2024 - embopress.org
Communications between immune cells are essential to ensure appropriate coordination of
their activities. Here, we observed the infiltration of activated macrophages into the joint-…
their activities. Here, we observed the infiltration of activated macrophages into the joint-…
Preclinical evaluation of 111In-labeled PEGylated maytansine nimotuzumab drug conjugates in EGFR-positive cancer models
SV Hartimath, E Alizadeh, VR Solomon… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Epidermal growth factor receptor I (EGFR) is overexpressed in most cancers of epithelial origin.
Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise …
Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise …
Examining immunotherapy response using multiple radiotracers
JL Goggi, SV Hartimath, Y Hwang, YX Tan… - Molecular Imaging and …, 2020 - Springer
Purpose Cancer immunotherapy has shown huge potential in the fight against cancer, but
only a small proportion of patients respond successfully to treatment. Non-invasive methods to …
only a small proportion of patients respond successfully to treatment. Non-invasive methods to …
[HTML][HTML] Imaging Kv1. 3 expressing memory T cells as a marker of immunotherapy response
Simple Summary Cancer immunotherapy has shown huge potential in the fight against
cancer but few patients respond durably to treatment. Durable immunological responses are …
cancer but few patients respond durably to treatment. Durable immunological responses are …
[HTML][HTML] Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft
SV Hartimath, A El-Sayed, A Makhlouf, W Bernhard… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Nimotuzumab is a humanized anti-epidermal growth factor receptor I (EGFR) monoclonal
antibody. We have developed antibody drug conjugates (ADCs) with nimotuzumab conjugated …
antibody. We have developed antibody drug conjugates (ADCs) with nimotuzumab conjugated …
[HTML][HTML] [99mTc] O2-AMD3100 as a SPECT tracer for CXCR4 receptor imaging
SV Hartimath, UM Domanska, AME Walenkamp… - Nuclear Medicine and …, 2013 - Elsevier
PURPOSE: CXCR4 plays an important role in HIV infection, tumor progression, neurogenesis,
and inflammation. In-vivo imaging of CXCR4 could provide more insight in the role of this …
and inflammation. In-vivo imaging of CXCR4 could provide more insight in the role of this …