Single-chain Fv antibody fragments from the CD20-specific murine monoclonal antibody
B9E9 were genetically engineered as streptavidin fusions [single-chain Fv-streptavidin (scFvSA…

We reported defective efferocytosis associated with cigarette smoking and/or airway
inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe …

Multistep targeting can improve the therapeutic index of antibody-based targeting, particularly
relevant to pediatric tumors where acute toxicity and late effects of treatment are major …

Idelalisib, a potent phosphatidylinositol‐3‐kinase delta (PI3Kδ) inhibitor, is metabolized
primarily by aldehyde oxidase to form GS‐563117 and to a lesser extent by cytochrome P450 (…

Jasmonic acid, methyl jasmonate, and salicylic acid have been reported to occur in plants
and are thought to be essential for the regulation of systemic defense responses. This work …

Mucus clearance is an important component of the lung's innate defense system. A failure of
this system brought on by mucus dehydration is common to both cystic fibrosis (CF) and …

Herein, we describe the synthesis of Pyk2 inhibitors via macrocyclization of FAK and dual
Pyk2-FAK inhibitors. We identified macrocycle 25a as a highly potent Pyk2 inhibitor (IC 50 = …

3-(Acylamino)glutarimides, a class of broad spectrum chemokine inhibitors, are rapidly
hydrolyzed in serum, despite being stable in aqueous solution. Synthesis and high-performance …

Two new diastereomeric homoditerpene peroxides were isolated from the aerial parts of
wormwood. The mixture of both compounds showed antimalarial activity in in vitro tests with …

Wounding hybrid poplar (Populus trichocarpa × P. deltoides) trees results in the expression
of novel wound-inducible (win) mRNAs thought to encode proteins involved in defense …