Iron deficiency and iron overload are among the most prevalent nutritional disorders worldwide.
Duodenal cytochrome b (DcytB) and divalent metal transporter 1 (DMT1) are regulators …

Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation
of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, …

We report here the identification of mouse βklotho (βkl), which encodes a type I membrane
protein with high resemblance to Klotho (KL). Both βKL and KL consist of two internal repeats …

We have generated a line of mutant mouse that lacks βKlotho, a protein that structurally
resembles Klotho. The synthesis and excretion of bile acids were found to be dramatically …

α-Klotho (α-Kl) and its homolog, β-Klotho (β-Kl) are key regulators of mineral homeostasis
and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, …

Background & Aims: Colon epithelial cells are critical for barrier function and contain a
highly developed immune response. A previous study has shown hypoxia-inducible factor (HIF) …

Upon contact with biofluids, proteins are quickly adsorbed onto the nanoparticle (NP) surface
to form a protein corona, which initiates the opsonization and facilitates the rapid clearance …

To determine the impact of the species difference between rodents and humans in response
to peroxisome proliferators (PPs) mediated by peroxisome proliferator–activated receptor (…

Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …

We have identified a novel mouse gene klph (Klotho-LPH related protein; where LPH stands
for lactase-phlorizin hydrolase) that encodes a novel mammalian family 1 glycosidase-like …