B cell activation following antigen receptor cross-linking can be augmented in vitro by ligation
of cell surface CD22, which associates with the SHP1 protein tyrosine phosphatase. The …

Signaling thresholds influence the balance between humoral immunity and autoimmunity.
Cell surface CD19 regulates intrinsic and Ag receptor-induced B lymphocyte signaling …

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity. Design, …

CD19 serves as a cell surface response regulator that establishes signaling thresholds critical
for B lymphocyte development and activation. B lymphocytes from CD19-deficient mice …

A photocatalyst ([Ru (bpy) 3] 2+) bound to a protein ligand was essential for the title method.
Local single‐electron transfer from the catalyst resulted in the formation of tyrosyl radicals. N…

Systemic sclerosis (SSc) is a connective tissue disease characterized by excessive
extracellular matrix deposition in the skin and visceral organs. SSc is associated with immune …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Background To help adapt cardiovascular disease risk prediction approaches to low-income
and middle-income countries, WHO has convened an effort to develop, evaluate, and …

CD19deficient mice were generated to examlne the role of CD18 in B cell growth regulation
in vivo. Deletion of CD19 had no deleterious effects on the generation of 6 cells in the bone …

Connective tissue growth factor (CTGF) is a novel peptide that exhibits platelet-derived growth
factor-like activities and is produced by skin fibroblasts after activation with transforming …