Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most abundant
non-protein thiol that defends against oxidative stress. GSH is also a key determinant of …

Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from
antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol of all …

Exosomes represent a discrete population of vesicles that are secreted from various cell
types to the extracellular media. Their protein and lipid composition are a consequence of …

S-Adenosyl-lmethionine (SAM) is an important molecule in normal cell function and survival.
SAM is utilized by three key metabolic pathways: transmethylation; transsulfuration; and …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver. …

Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products
of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-…

Genome sequence analysis reveals that all organisms synthesize S-adenosylmethionine (AdoMet)
and that a large fraction of all genes is AdoMet-dependent methyltransferases. …

OBJECTIVES: Chronic infection with hepatitis C virus (HCV) was previously the leading
indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-…

Alcoholic liver disease (ALD) develops as a consequence of priming and sensitizing mecha
nisms rendered by cross‐interactions of primary mech anistic factors and secondary risk …