Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM
352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing …

Purpose: Upregulation of programmed death-ligand 1 (PD-L1) on circulating and tumor-infiltrating
myeloid cells is a critical component of GBM-mediated immunosuppression that has …

Study Design Systematic literature review. Objective The management of traumatic
thoracolumbar burst fractures (TLBF) remains challenging, and analyzing the levels of evidence (…

Poor tissue penetration remains a major challenge for antibody-based therapeutics of solid
tumors, but proper dosing can improve the tissue penetration and thus therapeutic efficacy of …

Although surgical resection has been the primary treatment modality of solid tumors for
decades, surgeons still rely on visual cues and palpation to delineate healthy from cancerous …

Object The overall evidence for nonoperative management of patients with traumatic
thoracolumbar burst fractures is unknown. There is no agreement on the optimal method of …

Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a
result, surgeons focus on harvesting significant numbers of LNs during ablative procedures …

Background Complete surgical resection remains the primary curative option for pancreatic
ductal adenocarcinoma, with positive margins in 30–70% of patients. In this study, we aimed …

Current adjuvant treatment regimens available for the treatment of glioblastoma are widely
ineffective and offer a dismal prognosis. Advancements in conventional treatment strategies …

Purpose To identify the optimal dosing strategy for fluorescence-guided surgery in patients
with head and neck squamous cell carcinoma, we conducted a dose-ranging study …