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Shanmugasundaram Ganapathy-Kanniappan

Assistant Professor, Johns Hopkins University School of Medicine
Verified email at jhmi.edu
Cited by 2876

[HTML][HTML] Tumor glycolysis as a target for cancer therapy: progress and prospects

S Ganapathy-Kanniappan, JFH Geschwind - Molecular cancer, 2013 - Springer
Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of
the “hallmarks of cancer”. This metabolic phenotype is characterized by preferential …

Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype

S Ganapathy-Kanniappan - Critical reviews in biochemistry and …, 2018 - Taylor & Francis
Aerobic glycolysis is the process of oxidation of glucose into pyruvate followed by lactate
production under normoxic condition. Distinctive from its anaerobic counterpart (ie glycolysis …

Linking tumor glycolysis and immune evasion in cancer: emerging concepts and therapeutic opportunities

S Ganapathy-Kanniappan - Biochimica et Biophysica Acta (BBA)-Reviews …, 2017 - Elsevier
Metabolic reprogramming and immune evasion are two hallmarks of cancer. Metabolic
reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential rate …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death

S Ganapathy-Kanniappan, JFH Geschwind… - Anticancer …, 2009 - ar.iiarjournals.org
Background: The pyruvic acid analog 3-bromopyruvate (3BrPA) is an alkylating agent known
to induce cancer cell death by blocking glycolysis. The anti-glycolytic effect of 3BrPA is …

Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study

…, O Acha-Ngwodo, G Shanmugasundaram… - … of Pharmacology and …, 2008 - ASPET
The aim of this study was to determine the biodistribution and tumor targeting ability of 14 C-labeled
3-bromopyruvate ([ 14 C]3-BrPA) after ia and iv delivery in the VX2 rabbit model. In …

A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia

MA McDevitt, J Xie, S Ganapathy-Kanniappan… - The Journal of …, 2006 - rupress.org
The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for
its high mortality are poorly understood. Studies indicate that host mediators produced during …

[HTML][HTML] Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma

S Ganapathy-Kanniappan, R Kunjithapatham… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most highly lethal malignancies ranking as
the third leading-cause of cancer-related death worldwide. Although surgical resection and …

Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting

S Ganapathy-Kanniappan, R Kunjithapatham… - Anticancer …, 2013 - ar.iiarjournals.org
The anticancer efficacy of the pyruvate analog 3-bromopyruvate has been demonstrated in
multiple tumor models. The chief principle underlying the antitumor effects of 3-…

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

…, S Sur, LJ Savic, S Ganapathy-Kanniappan… - Clinical Cancer …, 2014 - AACR
Purpose: This study characterized the therapeutic efficacy of a systemically administered
formulation of 3-bromopyruvate (3-BrPA), microencapsulated in a complex with β-cyclodextrin (…

3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines

S Ganapathy-Kanniappan, JFH Geschwind… - Anticancer …, 2010 - ar.iiarjournals.org
Background: Autophagy, a cellular response to stress, plays a role in resistance to
chemotherapy in cancer cells. Resistance renders systemic chemotherapy generally ineffective …