Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET
…, C Zavaleta, PK Vuppala, S Jamalapuram… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The noninvasive imaging of σ-1 receptors (S1Rs) could provide insight into their role in
different diseases and lead to novel diagnostic/treatment strategies. The main objective of this …
different diseases and lead to novel diagnostic/treatment strategies. The main objective of this …
Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine
…, AH Abdelazeem, C Mesangeau, S Jamalapuram… - The AAPS journal, 2012 - Springer
Methamphetamine interacts with sigma receptors at physiologically relevant concentrations
suggesting a potential site for pharmacologic intervention. In the present study, a previous …
suggesting a potential site for pharmacologic intervention. In the present study, a previous …
Development and validation of sensitive LC/MS/MS method for quantitative bioanalysis of levonorgestrel in rat plasma and application to pharmacokinetics study
S Ananthula, DR Janagam, S Jamalapuram… - … of Chromatography B, 2015 - Elsevier
Rapid, sensitive, selective and accurate LC/MS/MS method was developed for quantitative
determination of levonorgestrel (LNG) in rat plasma and further validated for specificity, …
determination of levonorgestrel (LNG) in rat plasma and further validated for specificity, …
Development and validation of a UPLC‐MS/MS method for the determination of 7‐hydroxymitragynine, a μ‐opioid agonist, in rat plasma and its application to a …
PK Vuppala, S Jamalapuram, EB Furr… - Biomedical …, 2013 - Wiley Online Library
A simple, sensitive and specific ultra‐performance liquid chromatography–tandem mass
spectrometry (UPLC‐MS/MS) method was developed and validated to determine the …
spectrometry (UPLC‐MS/MS) method was developed and validated to determine the …
Ultra‐performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application …
S Jamalapuram, PK Vuppala… - Biomedical …, 2013 - Wiley Online Library
Methamphetamine abuse continues as a major problem in the USA owing to its powerful
psychological addictive properties. AZ66, 3‐[4‐(4‐cyclohexylpiperazine‐1‐yl)pentyl]‐6‐…
psychological addictive properties. AZ66, 3‐[4‐(4‐cyclohexylpiperazine‐1‐yl)pentyl]‐6‐…
Quantification of highly selective sigma‐1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre‐clinical …
BA Avery, PK Vuppala, S Jamalapuram… - Drug testing and …, 2017 - Wiley Online Library
An ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS)
method was developed and validated for quantification of CM304, a novel and highly selective …
method was developed and validated for quantification of CM304, a novel and highly selective …
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its …
S Jamalapuram, PK Vuppala, C Mesangeau… - … of Chromatography B, 2012 - Elsevier
A selective, rapid and sensitive ultra performance liquid chromatography mass spectrometry
(UPLC/MS) method was developed and validated to quantitate a highly selective mixed-…
(UPLC/MS) method was developed and validated to quantitate a highly selective mixed-…
Metabolic Stability And Pharmacokinetics In Lead Optimization Of Potential Anti-Psychostimulant Pharmacotherapies
S Jamalapuram - 2013 - egrove.olemiss.edu
Drug addiction is a chronic disorder characterized by obsessive and uncontrollable drug-seeking
behaviors. It is a major public health problem globally as well as in the United States. …
behaviors. It is a major public health problem globally as well as in the United States. …
Preclinical efficacy of the dual sigma receptor antagonist dopamine uptake inhibitor, CM699, as a medication for stimulant abuse (803.3)
…, T Kopajtic, M Coggiano, S Jamalapuram… - The FASEB …, 2014 - Wiley Online Library
Sigma receptor (σR) antagonists block many effects of stimulants, but not reinforcing effects
assessed with self‐administration (SA). Yet, a recent study suggests that σR antagonism with …
assessed with self‐administration (SA). Yet, a recent study suggests that σR antagonism with …
Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
PK Vuppala - 2012 - egrove.olemiss.edu
… I would like to give a big thank you to my wife, Seshulatha Jamalapuram. Without her I would
be a very different person today, and it would have been certainly much harder to finish my …
be a very different person today, and it would have been certainly much harder to finish my …