Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology
of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in …

Epigenetic mechanisms are involved in the pathophysiology of depressive disorders and
are unique potential targets for therapeutic intervention. The acetylating agent L-acetylcarnitine …

Excitatory amino acids play a key role in both adaptive and deleterious effects of stressors
on the brain, and dysregulated glutamate homeostasis has been associated with psychiatric …

The long-term consequences of a physiological-range increase of maternal corticosterone
during lactation were investigated on the 15-month-old progeny. The offspring of rats drinking …

It is well known that housing conditions may alter several physiological and behavioral
parameters. In this study, we have investigated whether a prolonged period of partial social …

Oleoylethanolamide (OEA) is a biologically active lipid amide that is released by small-intestinal
enterocytes during the absorption of dietary fat and inhibits feeding by engaging the …

Alzheimer’s disease, which is characterized by gradual cognitive decline associated with
deterioration of daily living activities and behavioral disturbances throughout the course of the …

The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology
of psychiatric disorders, including schizophrenia. We report here that the kynurenine …

Prolonged stress predisposes susceptible individuals to a number of physiological disorders
including cardiovascular disease, obesity and gastrointestinal disorders, as well as …

In order to test the hypothesis that maternal corticosterone influences hypothalamus-pituitary-adrenal
(HPA) system activity in the adult rat and behaviors related to it, we induced a …