18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study

M Ogawa, S Ishino, T Mukai, D Asano… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The rupture of atherosclerotic plaques and the subsequent formation of thrombi are the
main factors responsible for myocardial and cerebral infarctions. Thus, the detection of …

In vivo PET imaging of HDL in multiple atherosclerosis models

…, L Giesen, CH Wessel, J Witjes, S Ishino… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives : The goal of this study was to develop and validate a noninvasive imaging tool to
visualize the in vivo behavior of high-density lipoprotein (HDL) by using positron emission …

Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors

…, T Mukai, H Tamamura, T Mori, S Ishino… - Nuclear medicine and …, 2006 - Elsevier
The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important
role in tumor metastasis. The aim of this study was to develop a radiopharmaceutical for the …

Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques

…, Y Magata, T Kato, K Hatano, S Ishino… - Journal of Nuclear …, 2006 - Soc Nuclear Med
The rupture of atherosclerotic vulnerable plaques and subsequent formation of thrombi are
the main factors responsible for myocardial and cerebral infarctions. Because macrophage …

Imaging macrophage and hematopoietic progenitor proliferation in atherosclerosis

…, J Tang, C Pérez-Medina, V Mani, S Ishino… - Circulation …, 2015 - Am Heart Assoc
Rationale: Local plaque macrophage proliferation and monocyte production in hematopoietic
organs promote progression of atherosclerosis. Therefore, noninvasive imaging of …

Comparison of contrast agents for atherosclerosis imaging using cultured macrophages: FDG versus ultrasmall superparamagnetic iron oxide

T Satomi, M Ogawa, I Mori, S Ishino… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Various noninvasive imaging methods have been developed to evaluate atherosclerotic
plaques. Among them, 18 F-FDG PET and MR imaging with ultrasmall superparamagnetic iron …

Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability—analysis in hypercholesterolemic rabbits

S Ishino, T Mukai, N Kume, D Asano, M Ogawa, Y Kuge… - Atherosclerosis, 2007 - Elsevier
Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL (Ox-LDL),
has been implicated in vascular cell dysfunction related to atherosclerotic plaque …

Nanobody-facilitated multiparametric PET/MRI phenotyping of atherosclerosis

…, C Calcagno, J Tang, A Alaarg, Y Zhao, S Ishino… - JACC: Cardiovascular …, 2019 - jacc.org
Objectives : This study sought to develop an integrative positron emission tomography (PET)
with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque …

Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti–LOX-1 antibody: potential agent for imaging of vulnerable plaque

S Ishino, T Mukai, Y Kuge, N Kume… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Lectinlike oxidized low-density lipoprotein (LDL) receptor 1 (LOX-1), a cell surface receptor
for oxidized LDL, has been implicated in vascular cell dysfunction related to plaque instability…

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

…, MMT van Leent, J Malkus, S Baxter, S Ishino… - Science translational …, 2019 - science.org
Nanomedicine research produces hundreds of studies every year, yet very few formulations
have been approved for clinical use. This is due in part to a reliance on murine studies, …