Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging

…, A Seidlitz, A Bandurska-Luque, S Zschaeck… - Radiotherapy and …, 2017 - Elsevier
Background Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a
number of anticancer drugs and potentially immunotherapy. In a previously published …

[HTML][HTML] GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy

…, NH Stoecklein, M Toma, U Sommer, S Zschaeck… - Theranostics, 2021 - ncbi.nlm.nih.gov
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and …

[HTML][HTML] Non-thermal effects of radiofrequency electromagnetic fields

…, B Kortüm, U Strauss, J Nadobny, S Zschaeck… - Scientific Reports, 2020 - nature.com
We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and
established a theoretical framework to elucidate their electrophysiological mechanisms. In …

[HTML][HTML] Organ preservation in rectal cancer: the patients' perspective

C Gani, N Gani, S Zschaeck, F Eberle… - Frontiers in …, 2019 - frontiersin.org
Organ preservation after a clinical complete response to radiochemotherapy is currently
one of the most discussed topics in the management of rectal cancer. However, the patients' …

Individual patient data meta-analysis of FMISO and FAZA hypoxia PET scans from head and neck cancer patients undergoing definitive radio-chemotherapy

S Zschaeck, S Löck, F Hofheinz, D Zips… - Radiotherapy and …, 2020 - Elsevier
Background and purpose Tumor hypoxia plays an important role in head and neck squamous
cell carcinomas (HNSCC). Various positron emission tomography (PET) tracers promise …

Spatial distribution of FMISO in head and neck squamous cell carcinomas during radio-chemotherapy and its correlation to pattern of failure

S Zschaeck, R Haase, N Abolmaali, R Perrin… - Acta …, 2015 - Taylor & Francis
Background. Tumour hypoxia can be measured by FMISO-PET and negatively impacts
local tumour control in patients with head and neck squamous cell carcinoma (HNSCC) …

CT imaging during treatment improves radiomic models for patients with locally advanced head and neck cancer

S Leger, A Zwanenburg, K Pilz, S Zschaeck… - Radiotherapy and …, 2019 - Elsevier
Background and purpose The development of radiomic risk models to predict clinical outcome
is usually based on pre-treatment imaging, such as computed tomography (CT) scans …

Confirmation of the prognostic value of pretherapeutic tumor SUR and MTV in patients with esophageal squamous cell carcinoma

…, C Lili, W Hua, J van den Hoff, S Zschaeck - European Journal of …, 2019 - Springer
Purpose The prognosis for patients with inoperable esophageal carcinoma is still poor and
the reliability of individual therapy outcome prediction based on clinical parameters is not …

[HTML][HTML] PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives

S Zschaeck, F Lohaus, M Beck, G Habl, S Kroeze… - Radiation …, 2018 - Springer
68 Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography
(PET) is an increasingly used imaging modality in prostate cancer, especially in cases of …

[HTML][HTML] Metabolic parameters of sequential 18F-FDG PET/CT predict overall survival of esophageal cancer patients treated with (chemo-) radiation

Y Li, S Zschaeck, Q Lin, S Chen, L Chen, H Wu - Radiation oncology, 2019 - Springer
Background To evaluate the prognostic value of metabolic parameters of pre-treatment and
interim 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for overall …