Biomaterial-associated infection: locating the finish line in the race for the surface

…, PC Jutte, JJAM van den Dungen, SAJ Zaat… - Science translational …, 2012 - science.org
Biomaterial-associated infections occur on both permanent implants and temporary devices
for restoration or support of human functions. Despite increasing use of biomaterials in an …

Antibacterial components of honey

PHS Kwakman, SAJ Zaat - IUBMB life, 2012 - Wiley Online Library
The antibacterial activity of honey has been known since the 19th century. Recently, the potent
activity of honey against antibiotic‐resistant bacteria has further increased the interest for …

[HTML][HTML] Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections

Y Liu, R Qin, SAJ Zaat, E Breukink… - Journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Antibacterial photodynamic therapy (APDT) has drawn increasing attention from the scientific
society for its potential to effectively kill multidrug-resistant pathogenic bacteria and for its …

[HTML][HTML] Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

…, FJ Muller, DW Hommes, SAJ Zaat… - Immunity, 2007 - cell.com
How the development of antibacterial T helper 17 (Th17) cells is selectively promoted by
antigen-presenting dendritic cells (DCs) is unclear. We showed that bacteria, but not viruses, …

How honey kills bacteria

…, SAJ Zaat - The FASEB …, 2010 - Wiley Online Library
With the rise in prevalence of antibioticresistant bacteria, honey is increasingly valued for its
antibacterial activity. To characterize all bactericidal factors in a medical‐grade honey, we …

[HTML][HTML] Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines

J Krijgsveld, SAJ Zaat, J Meeldijk… - Journal of Biological …, 2000 - ASBMB
Antibacterial proteins are components of the innate immune system found in many organisms
and produced by a variety of cell types. Human blood platelets contain a number of …

Cross-linking and characterisation of gelatin matrices for biomedical applications

…, GHM Engbers, J Krijgsveld, SAJ Zaat… - Journal of …, 2000 - Taylor & Francis
Cross-linking of gelatin A and B with N,N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide
hydrochloride (EDC) and N-hydroxysuccinimide (NHS) was optimised by varying the NHS/ …

[HTML][HTML] Two major medicinal honeys have different mechanisms of bactericidal activity

…, L de Boer, CMJE Vandenbroucke-Grauls, SAJ Zaat - PloS one, 2011 - journals.plos.org
Honey is increasingly valued for its antibacterial activity, but knowledge regarding the
mechanism of action is still incomplete. We assessed the bactericidal activity and mechanism of …

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

…, A El Ghalbzouri, K Lohner, SAJ Zaat… - Science translational …, 2018 - science.org
Development of novel antimicrobial agents is a top priority in the fight against multidrug-resistant
(MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial and …

[HTML][HTML] Serum stabilities of short tryptophan-and arginine-rich antimicrobial peptide analogs

LT Nguyen, JK Chau, NA Perry, L de Boer, SAJ Zaat… - PloS one, 2010 - journals.plos.org
Background Several short antimicrobial peptides that are rich in tryptophan and arginine
residues were designed with a series of simple modifications such as end capping and …