Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and
survive. Many cancers show altered glucose metabolism, which constitutes the basis for in …

The specificity of antibodies have made immunoconjugates promising vectors for the delivery
of radioisotopes to cancer cells; however, their long pharmacologic half-lives necessitate …

The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell
lung cancer (SCLC) and high-grade neuroendocrine carcinomas. Rovalpituzumab teserine (…

Purpose Dual-modality PET/MR platforms add a new dimension to patient diagnosis with
high resolution, functional, and anatomical imaging. The full potential of this emerging hybrid …

We evaluated the ability of the PET imaging agent 89 Zr-trastuzumab to delineate HER2-positive
gastric cancer and to monitor the pharmacodynamic effects of the epidermal growth …

Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid
clearance from nontumor tissues. Here, we demonstrate that positron emission tomography (…

Purpose The current study presents [ 18 F]PARPi-FL as a bimodal fluorescent/positron emission
tomography (PET) agent for PARP1 imaging. Procedures [ 18 F]PARPi-FL was obtained …

The complementary nature of positron emission tomography (PET) and optical imaging (OI)
has fueled increasing interest in the development of multimodal PET/OI probes that can be …

Solid tumors often develop an acidic microenvironment, which plays a critical role in tumor
progression and is associated with increased level of invasion and metastasis. The 37-…

Extracellular acidity is associated with tumor progression. Elevated glycolysis and acidosis
promote the appearance of aggressive malignant cells with enhanced multidrug resistance. …