Objective To characterize the prevalence of amyloid deposition in a clinically unimpaired
elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission …

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds
with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in …

A valid quantitative imaging method for the measurement of amyloid deposition in humans
could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our …

PET studies have been performed using the amyloid binding radiotracer Pittsburgh
Compound B (PIB). Previous quantitative analyses using arterial blood showed that the Logan …

The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-β
protein is an initiating event in Alzheimer's disease (AD). Using amyloid imaging technology…

BACKGROUND: Several lines of evidence support the possibility that disturbances of
dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and …

Context Previous studies have shown that women with anorexia nervosa (AN), when ill and
after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder …

Depression in late life carries an increased risk of dementia and brittle response to treatment.
There is growing evidence to support a key role of the serotonin type 1A (5-HT 1A) receptor …

BACKGROUND: Individuals who are ill with anorexia (AN) and bulimia nervosa (BN) often
have increased cerebrospinal fluid (CSF) volumes and decreased total gray and white matter …

BACKGROUND: Many studies have found disturbances of serotonin (5-HT) activity in
anorexia nervosa (AN). Because little is known about 5-HT receptor function in AN, positron …