The purpose of this study was to develop a method of registering 18 F-FDG PET with MR
permeability images for investigating the correlation of 18 F-FDG uptake, permeability, and …

Exome sequencing — the targeted sequencing of the subset of the human genome that is
protein coding — is a powerful and cost-effective new tool for dissecting the genetic basis of …

Emulsion fuel is an unconventional fuel for diesel engines, which can be used without
modifications in the engine. The benefits of an emulsion fuel include lowering the emissions of …

Massively parallel sequencing has enabled the rapid, systematic identification of variants
on a large scale. This has, in turn, accelerated the pace of gene discovery and disease …

Genome-wide association studies suggest that common genetic variants explain only a
modest fraction of heritable risk for common diseases, raising the question of whether rare …

We demonstrate the first successful application of exome sequencing to discover the gene
for a rare mendelian disorder of unknown cause, Miller syndrome (MIM%263750). For four …

We demonstrate the successful application of exome sequencing 1 , 2 , 3 to discover a gene
for an autosomal dominant disorder, Kabuki syndrome (OMIM%147920). We subjected the …

Evidence for the etiology of autism spectrum disorders (ASDs) has consistently pointed to a
strong genetic component complicated by substantial locus heterogeneity 1 , 2 . We …

Background Large trials have shown that sodium glucose co-transporter-2 (SGLT2) inhibitors
reduce the risk of adverse kidney and cardiovascular outcomes in patients with heart …

RNA modifications, such as N 6 -methyladenosine (m 6 A), modulate functions of cellular
RNA species. However, quantifying differences in RNA modifications has been challenging. …