Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative
diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the …

The clinical syndromes of frontotemporal dementia are clinically and neuropathologically
heterogeneous, but processes such as neuroinflammation may be common across the disease …

Objective Mesial temporal lobe epilepsy ( MTLE ) is one of the most common types of the
intractable epilepsies and is most often associated with hippocampal sclerosis ( HS ), which is …

Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia
and Parkinson's disease, with effects on arousal, attention, cognitive and motor control. …

Antipsychotics are the most widely used medications for the treatment of schizophrenia
spectrum disorders. While such drugs generally ameliorate positive symptoms, clinical …

Background Necrotizing enterocolitis (NEC) is an acute gut inflammatory disorder that occurs
in preterm infants in the first weeks after birth. Infants surviving NEC often show impaired …

The relationship between in vivo synaptic density and molecular pathology in primary tauopathies
is key to understanding the impact of tauopathy on functional decline and in informing …

Decreased parvalbumin expression is a hallmark of the pathophysiology of schizophrenia
and has been associated with abnormal cognitive processing and decreased network …

Understanding the cellular underpinnings of neurodegeneration remains a challenge; loss
of synapses and dendritic arborization are characteristic and can be quantified in vivo, with [ …

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by
neuroglial tau pathology. A new staging system for PSP pathology postmortem has been …