Mechanisms of osteolytic bone metastases in breast carcinoma
SM Käkönen, GR Mundy - … International Journal of the …, 2003 - Wiley Online Library
Osteolytic and osteoblastic metastases are often the cause of considerable morbidity in
patients with advanced prostate and breast carcinoma. Breast carcinoma metastasis to bone …
patients with advanced prostate and breast carcinoma. Breast carcinoma metastasis to bone …
[HTML][HTML] Transforming growth factor-β stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase …
SM Käkönen, KS Selander, JM Chirgwin… - Journal of Biological …, 2002 - ASBMB
Transforming growth factor (TGF)-β promotes breast cancer metastasis to bone. To determine
whether the osteolytic factor parathyroid hormone-related protein (PTHrP) is the primary …
whether the osteolytic factor parathyroid hormone-related protein (PTHrP) is the primary …
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
S Pollari, SM Käkönen, H Edgren, M Wolf… - Breast cancer research …, 2011 - Springer
Since bone metastatic breast cancer is an incurable disease, causing significant morbidity
and mortality, an understanding of the underlying molecular mechanisms would be highly …
and mortality, an understanding of the underlying molecular mechanisms would be highly …
Radium-223 inhibits osseous prostate cancer growth by dual targeting of cancer cells and bone microenvironment in mouse models
…, D Mumberg, K Ziegelbauer, SM Käkönen… - Clinical Cancer …, 2017 - AACR
Purpose: Radium-223 dichloride (radium-223, Xofigo), a targeted alpha therapy, is currently
used for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone …
used for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone …
Urinary osteocalcin as a marker of bone metabolism
KK Ivaska, SM Kakonen, P Gerdhem… - Clinical …, 2005 - academic.oup.com
Background: Osteocalcin (OC) is produced by osteoblasts during bone formation, and
circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is …
circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is …
Survival benefit with radium-223 dichloride in a mouse model of breast cancer bone metastasis
MI Suominen, JP Rissanen, R Käkönen… - Journal of the …, 2013 - academic.oup.com
Background Bone metastases are associated with increased morbidity and poor prognosis
in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, …
in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, …
[HTML][HTML] Identification of microRNAs inhibiting TGF-β-induced IL-11 production in bone metastatic breast cancer cells
S Pollari, SK Leivonen, M Perälä, V Fey, SM Käkönen… - PloS one, 2012 - journals.plos.org
Development of bone metastases is dependent on the cancer cell-bone cell interactions in
the bone microenvironment. Transforming growth factor β (TGF-β) is released from bone …
the bone microenvironment. Transforming growth factor β (TGF-β) is released from bone …
Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis
S Pollari, RS Käkönen, KS Mohammad… - Molecular cancer …, 2012 - AACR
TGF-β regulates several steps in cancer metastasis, including the establishment of bone
metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it …
metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it …
Two‐site immunoassays for osteoclastic tartrate‐resistant acid phosphatase based on characterization of six monoclonal antibodies
…, P Laaksonen, J Hellman, SM Käkönen… - Journal of Bone and …, 1999 - academic.oup.com
Tartrate‐resistant acid phosphatase (TRAP), an enzyme expressed in bone‐resorbing
osteoclasts, is secreted into the circulation during bone resorption. We used six monoclonal …
osteoclasts, is secreted into the circulation during bone resorption. We used six monoclonal …
[HTML][HTML] The mode-of-action of targeted alpha therapy radium-223 as an enabler for novel combinations to treat patients with bone metastasis
MI Suominen, T Wilson, SM Käkönen… - International Journal of …, 2019 - mdpi.com
Bone metastasis is a common clinical complication in several cancer types, and it causes a
severe reduction in quality of life as well as lowering survival time. Bone metastases proceed …
severe reduction in quality of life as well as lowering survival time. Bone metastases proceed …