Endothelial cells (EC) metabolize l-arginine mainly by arginase, which exists as two distinct
isoforms, arginase I and II. To understand the roles of arginase isoforms in EC arginine …

Progressive photoreceptor degeneration resulting from genetic and other factors is a leading
and largely untreatable cause of blindness worldwide. The object of this study was to find a …

Objective To determine whether it is possible to engineer 3‐dimensional hyaline cartilage
using mesenchymal stem cells derived from the bone marrow (BMSCs) of patients with …

The boronic acid-based arginine analogue S-(2-boronoethyl)-l-cysteine (BEC) has been
synthesized and assayed as a slow-binding competitive inhibitor of the binuclear manganese …

Injuries to the avascular region of knee meniscal cartilage do not heal spontaneously. To
address this problem we have developed a new stem cell/collagen-scaffold implant system in …

The identification of stem cell–specific proteins and the elucidation of their novel regulatory
pathways may help in the development of protocols for control of their self-renewal and …

In early-stage breast cancer, the primary treatment option for most women is breast-conserving
surgery (BCS). There is a clear need for more accurate techniques to assess resection …

Because arginase hydrolyzes arginine to produce ornithine and urea, it has the potential to
regulate nitric oxide (NO) and polyamine synthesis. We tested whether expression of the …

Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a
potentially important mechanism for regulating the biological effects of agmatine in mammalian …

Background: Although expressed primarily in the liver, arginase activity also is present in
extrahepatic tissues and specifically in macrophages, where it may play diverse physiologic …