Background Human papillomavirus-related (HPV+) oropharyngeal cancer is a rapidly emerging
disease with generally good prognosis. Many prognostic algorithms for oropharyngeal …

In the setting of conventional radiation therapy, even when combined with immunotherapy,
head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is …

Purpose: Radiotherapy (RT) can transform the immune landscape and render poorly
immunogenic tumors sensitive to PD-L1 inhibition. Here, we established that the response to …

Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …

BACKGROUND Sinonasal malignancies are a rare and heterogeneous group of tumors for
which there is a paucity of robust data with which to guide management decisions. The …

In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation
therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased IL-2Rα …

Background Radioresistance represents a major problem in the treatment of head and neck
cancer (HNC) patients. To improve response, understanding tumor microenvironmental …

Immunotherapy clinical trials targeting the programmed-death ligand axis (PD-1/PD-L1) show
that most head and neck squamous cell carcinoma (HNSCC) patients are resistant to PD-1…

… Author Contributions: Drs Amini and Karam had full access to all the data in the study
and take responsibility for the integrity of the data and the accuracy of the data analysis. …

Radiation therapy has been used for many years to treat tumors based on its DNA-damage-mediated
ability to kill cells. More recently, RT has been shown to exert beneficial …