User profiles for Samuel Valable

Samuel Valable

CNRS researcher, ISTCT lab, CNRS
Verified email at cnrs.fr
Cited by 3556

[HTML][HTML] The role of hypoxia and SRC tyrosine kinase in glioblastoma invasiveness and radioresistance

…, L Salvatorelli, G Russo, G Cuttone, S Valable… - Cancers, 2020 - mdpi.com
Simple Summary The biological pathways underlying glioblastoma malignancy and radioresistance
are still unclear. In this review, we describe the role of the hypoxic microenvironment …

[HTML][HTML] Hypoxia imaging and adaptive radiotherapy: a state-of-the-art approach in the management of glioma

…, B Dubray, M Bernaudin, J Thariat, S Valable - Frontiers in …, 2019 - frontiersin.org
Severe hypoxia [oxygen partial pressure (pO 2 ) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the 1950s …

The reactive species interactome in the brain

E Malard, S Valable, M Bernaudin, E Pérès… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Redox pioneer Helmut Sies attempted to explain reactive species' challenges
faced by organelles, cells, tissues, and organs via three complementary definitions: (i) …

VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1

S Valable, J Montaner, A Bellail… - Journal of Cerebral …, 2005 - journals.sagepub.com
After cerebral ischemia, angiogenesis, by supplying for the deficient perfusion, may be a
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …

[PDF][PDF] Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal

R Abou-Khalil, F Le Grand, G Pallafacchina, S Valable… - Cell stem cell, 2009 - cell.com
Mechanisms governing muscle satellite cell withdrawal from cell cycle to enter into quiescence
remain poorly understood. We studied the role of angiopoietin 1 (Ang1) and its receptor …

Synergistic effects of CoCl2 and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells

E Pacary, H Legros, S Valable… - Journal of cell …, 2006 - journals.biologists.com
Bone-marrow-derived mesenchymal stem cells (MSCs) constitute an interesting cellular
source to promote brain regeneration after neurodegenerative diseases. Recently, several …

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

…, A Jonneaux, C Ballot, S Balayssac, S Valable… - Cancer research, 2012 - AACR
Cancer cells can undergo a metabolic reprogramming from oxidative phosphorylation to
glycolysis that allows them to adapt to nutrient-poor microenvironments, thereby imposing a …

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat

T Freret, S Valable, L Chazalviel… - European Journal of …, 2006 - Wiley Online Library
The mechanisms underlying functional recovery after stroke are poorly understood. Brain‐adaptive
responses to the hypoxic stress elicited by ischemia could contribute to these …

TNF receptor I sensitizes neurons to erythropoietin-and VEGF-mediated neuroprotection after ischemic and excitotoxic injury

…, M Mengozzi, ML Roberts, S Valable… - Proceedings of the …, 2008 - National Acad Sciences
CNS neurons use robust cytoprotective mechanisms to ensure survival and functioning
under conditions of injury. These involve pathways induced by endogenous neuroprotective …

Time-and cell type-specific induction of platelet-derived growth factor receptor-β during cerebral ischemia

O Renner, A Tsimpas, S Kostin, S Valable, E Petit… - Molecular brain …, 2003 - Elsevier
During cerebral ischemia, angiogenesis occurs inside and around the infarcted area. The
growth of new blood vessels may contribute to a better outcome after stroke due to accelerated …