User profiles for Samuel Valable
Samuel ValableCNRS researcher, ISTCT lab, CNRS Verified email at cnrs.fr Cited by 3556 |
[HTML][HTML] The role of hypoxia and SRC tyrosine kinase in glioblastoma invasiveness and radioresistance
Simple Summary The biological pathways underlying glioblastoma malignancy and radioresistance
are still unclear. In this review, we describe the role of the hypoxic microenvironment …
are still unclear. In this review, we describe the role of the hypoxic microenvironment …
[HTML][HTML] Hypoxia imaging and adaptive radiotherapy: a state-of-the-art approach in the management of glioma
…, B Dubray, M Bernaudin, J Thariat, S Valable - Frontiers in …, 2019 - frontiersin.org
Severe hypoxia [oxygen partial pressure (pO 2 ) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the 1950s …
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the 1950s …
The reactive species interactome in the brain
E Malard, S Valable, M Bernaudin, E Pérès… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Redox pioneer Helmut Sies attempted to explain reactive species' challenges
faced by organelles, cells, tissues, and organs via three complementary definitions: (i) …
faced by organelles, cells, tissues, and organs via three complementary definitions: (i) …
VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1
S Valable, J Montaner, A Bellail… - Journal of Cerebral …, 2005 - journals.sagepub.com
After cerebral ischemia, angiogenesis, by supplying for the deficient perfusion, may be a
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …
beneficial process for limiting neuronal death and promoting tissue repair. In this study, we …
[PDF][PDF] Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
R Abou-Khalil, F Le Grand, G Pallafacchina, S Valable… - Cell stem cell, 2009 - cell.com
Mechanisms governing muscle satellite cell withdrawal from cell cycle to enter into quiescence
remain poorly understood. We studied the role of angiopoietin 1 (Ang1) and its receptor …
remain poorly understood. We studied the role of angiopoietin 1 (Ang1) and its receptor …
Synergistic effects of CoCl2 and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells
Bone-marrow-derived mesenchymal stem cells (MSCs) constitute an interesting cellular
source to promote brain regeneration after neurodegenerative diseases. Recently, several …
source to promote brain regeneration after neurodegenerative diseases. Recently, several …
Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants
…, A Jonneaux, C Ballot, S Balayssac, S Valable… - Cancer research, 2012 - AACR
Cancer cells can undergo a metabolic reprogramming from oxidative phosphorylation to
glycolysis that allows them to adapt to nutrient-poor microenvironments, thereby imposing a …
glycolysis that allows them to adapt to nutrient-poor microenvironments, thereby imposing a …
Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat
The mechanisms underlying functional recovery after stroke are poorly understood. Brain‐adaptive
responses to the hypoxic stress elicited by ischemia could contribute to these …
responses to the hypoxic stress elicited by ischemia could contribute to these …
TNF receptor I sensitizes neurons to erythropoietin-and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
…, M Mengozzi, ML Roberts, S Valable… - Proceedings of the …, 2008 - National Acad Sciences
CNS neurons use robust cytoprotective mechanisms to ensure survival and functioning
under conditions of injury. These involve pathways induced by endogenous neuroprotective …
under conditions of injury. These involve pathways induced by endogenous neuroprotective …
Time-and cell type-specific induction of platelet-derived growth factor receptor-β during cerebral ischemia
O Renner, A Tsimpas, S Kostin, S Valable, E Petit… - Molecular brain …, 2003 - Elsevier
During cerebral ischemia, angiogenesis occurs inside and around the infarcted area. The
growth of new blood vessels may contribute to a better outcome after stroke due to accelerated …
growth of new blood vessels may contribute to a better outcome after stroke due to accelerated …