The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of dopamine …

In this study, we applied a tracer programmedinfusion technique (20, 21) with the SPECT
D2 receptor probe [†œ-@ I] IBZM (22) to establish a stable baseline for evaluation of the d-…

Neuroinflammation is a pathological hallmark of Alzheimer’s disease, but its role in cognitive
impairment and its course of development during the disease are largely unknown. To …

Single photon emission computed tomography (SPECT) studies of regional kinetic uptake
and pharmacological specificity of [ 123 I] methyl 3β‐ (4‐iodophenyl) tropane‐2β‐carboxylate (…

Ten percent of humans lack specific binding of [ 11 C]PBR28 to 18 kDa translocator protein (TSPO),
a biomarker for inflammation. “Non-binders” have not been reported using another …

Neuroimaging studies have documented an age-related decline in striatal dopamine
transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further …

The impact of endogenous dopamine on in vivo measurement of D 2 receptors in humans
was evaluated with single photon emission computerized tomography (SPECT), by comparing …

OBJECTIVE: Evidence of a relationship between genotype and binding availability was
assessed for the dopamine and serotonin transporter genes. METHOD: The authors assessed …

Second-generation radioligands for translocator protein (TSPO), an inflammation marker,
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …

The competition between endogenous transmitters and radiolabeled ligands for in vivo binding
to neuroreceptors might provide a method to measure endogenous transmitter release in …