Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease: PET evidence of increased dopamine turnover
…, JQ Lu, V Sossi, S Jivan… - Annals of …, 2001 - Wiley Online Library
Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease.
To investigate whether such oscillations in mobility can be attributed to changes in the …
To investigate whether such oscillations in mobility can be attributed to changes in the …
A PET imaging strategy to visualize activated T cells in acute graft-versus-host disease elicited by allogenic hematopoietic cell transplant
…, HF VanBrocklin, R Hawkins, BL Franc, S Jivan… - Cancer research, 2017 - AACR
A major barrier to successful use of allogeneic hematopoietic cell transplantation is acute
graft-versus-host disease (aGVHD), a devastating condition that arises when donor T cells …
graft-versus-host disease (aGVHD), a devastating condition that arises when donor T cells …
Simultaneous 68Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor
…, E Nakakura, H VanBrocklin, J Slater, S Jivan… - Abdominal …, 2015 - Springer
Objective To evaluate a simultaneous PET/MRI approach to imaging patients with
neuroendocrine tumor using a combination of 68 Ga-DOTA-TOC as a PET contrast agent and …
neuroendocrine tumor using a combination of 68 Ga-DOTA-TOC as a PET contrast agent and …
Imaging of activated T cells as an early predictor of immune response to anti-PD-1 therapy
…, T Lam, SR Goth, S Yaghoubi, J Bates, G Ren, S Jivan… - Cancer research, 2019 - AACR
These findings reveal differences in T-cell activation between responders and
nonresponders early into anti-PD-1 treatment, which may impact many facets of immuno-oncology, …
nonresponders early into anti-PD-1 treatment, which may impact many facets of immuno-oncology, …
Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers
…, MN Stewart, R Sriram, MA Yu, S Jivan… - ACS central …, 2020 - ACS Publications
Incorporation of d-amino acids into peptidoglycan is a unique metabolic feature of bacteria.
Since d-amino acids are not metabolic substrates in most mammalian tissues, this difference …
Since d-amino acids are not metabolic substrates in most mammalian tissues, this difference …
A high-affinity [18 F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer
…, S Murphy, H Cahaya, JE Blecha, S Jivan… - Nuclear medicine and …, 2015 - Elsevier
Introduction In this study, a structurally modified phosphoramidate scaffold, with improved
prostate-specific membrane antigen (PSMA) avidity, stability and in vivo characteristics, as a …
prostate-specific membrane antigen (PSMA) avidity, stability and in vivo characteristics, as a …
Phase I study of CTT1057, an 18F-labeled imaging agent with phosphoramidate core targeting prostate-specific membrane antigen in prostate cancer
…, K Gao, EJ Small, J Blecha, S Jivan… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Agents targeting prostate-specific membrane antigen (PSMA) comprise a rapidly emerging
class of radiopharmaceuticals for diagnostic imaging of prostate cancer. Unlike most other …
class of radiopharmaceuticals for diagnostic imaging of prostate cancer. Unlike most other …
High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection
MN Stewart, MFL Parker, S Jivan, JM Luu… - ACS Infectious …, 2019 - ACS Publications
Currently, there exists no accurate, noninvasive clinical imaging method to detect living
bacteria in vivo. Our goal is to provide a positron emission tomography (PET) method to image …
bacteria in vivo. Our goal is to provide a positron emission tomography (PET) method to image …
Structure–Activity Relationship of 18F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET …
…, L Skultetyova, CR Drake, S Jivan… - Journal of medicinal …, 2016 - ACS Publications
A series of phosphoramidate-based prostate specific membrane antigen (PSMA) inhibitors
of increasing lipophilicity were synthesized (4, 5, and 6), and their fluorine-18 analogs were …
of increasing lipophilicity were synthesized (4, 5, and 6), and their fluorine-18 analogs were …
In vivo PET imaging of the activated immune environment in a small animal model of inflammatory arthritis
…, X Li, J Blecha, T Lam, S Jivan… - Molecular …, 2017 - journals.sagepub.com
Background: Evolving immune-mediated therapeutic strategies for rheumatoid arthritis (RA)
may benefit from an improved understanding of the complex role that T-cell activation plays …
may benefit from an improved understanding of the complex role that T-cell activation plays …