About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary
substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC …

The protein alpha-synuclein (αSYN) plays a central role in synucleinopathies such as
Parkinsons's disease (PD) and multiple system atrophy (MSA). Presently, there are no selective …

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for
the treatment of Parkinson’s disease. However, brain penetration of antibodies is hampered …

Visualization of amyloid-β (Aβ) pathology with PET has become an important tool for making
a specific clinical diagnosis of Alzheimer disease (AD). However, the available amyloid PET …

PET imaging of amyloid-β (Aβ) has become an important component of Alzheimer disease
diagnosis. C-Pittsburgh compound B ( 11 C-PiB) and analogs bind to fibrillar Aβ. However, …

The positron emission tomography (PET) radioligand [ 11 C]UCB-J binds to synaptic vesicle
protein 2A (SV2A) and is used to investigate synaptic density in the living brain. Clinical …

The blood-brain barrier (BBB) is suggested to be compromised in Alzheimer's disease (AD).
The concomitant presence of vascular amyloid beta (Aβ) pathology, so called cerebral …

Background Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ)
deposits in Alzheimer’s disease (AD). In the present study, we compared the therapeutic …

Background The proper establishment of hypothalamic feeding circuits during early development
has a profound influence on energy homeostasis, and perturbing this process could …

The B 0 AT2 protein is a product of the SLC6A15 gene belonging to the SLC6 subfamily and
has been shown to be a transporter of essential branched-chain amino acids. We aimed to …