[ 11 C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a
specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not …

This work examines the inter-relationship between the unbound drug fractions in blood and
brain homogenate, passive membrane permeability, P-glycoprotein (Pgp) efflux ratio, and …

Microglial activation has been linked with deficits in neuronal function and synaptic plasticity
in Alzheimer's disease (AD). The mitochondrial translocator protein (TSPO) is known to be …

Purpose The treatment of complex neurological diseases often requires the administration of
large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into …

The radiotracer [18F]-fluoro-3, 4-dihydroxyphenyl-L-alanine ([18F]-FDOPA) has been used
to noninvasively study presynaptic dopamine synthesis capacity in the human brain using …

A series of analogues of the pyrazole lead 1 were synthesized in which the heterocyclic
core was replaced with an imidazole. A number of potent antagonists were identified and …

Purpose There is robust evidence that people with schizophrenia show elevated dopamine (DA)
synthesis capacity in the striatum. This finding comes from positron emission …

Deficits in neuronal function and synaptic plasticity in Alzheimer’s disease (AD) are believed
to be linked to microglial activation. A hallmark of reactive microglia is the upregulation of …

Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6
integrin occupancy using positron emission tomography in rodent lung | European Journal of …

Oxytocin is known to be implicated in a variety of functions, such as learning, stress, anxiety,
feeding, and pain perception. Oxytocin is also important for social memory and attachment, …