Cellular levels of key regulatory proteins are controlled via ubiquitination and subsequent
degradation. Deubiquitinating enzymes or isopeptidases can potentially prevent targeted …

The androgen-regulated enzyme fatty acid synthase (FAS), required for de novo lipogenesis,
is overexpressed in several cancers including prostate carcinoma and has been …

Purpose The widespread use of abdominal imaging has affected the epidemiology of renal
cell carcinoma (RCC). Despite this, over 25% of individuals with RCC have evidence of …

In this review, we briefly summarize the main features and updates of each chapter of the
inaugural WHO Classification of Pediatric Tumors, including its rapid transition from a mostly …

Atypical teratoid/rhabdoid tumors (AT/RTs) are highly aggressive brain tumors of early
childhood poorly responding to therapy. The majority of cases show inactivation of SMARCB1 (…

Purpose Following curative treatment for localised renal cell carcinoma (RCC), up to 30% of
patients develop tumour recurrence. Prognostic scores are essential to guide individualised …

Novelli M, Rossi S, Rodriguez‐Justo M, Taniere P, Seddon B, Toffolatti L, Sartor C, Hogendoorn
PCW, Sciot R, Van Glabbeke M, Verweij J, Blay JY, Hohenberger P, Flanagan A & Dei …

FLI-1 nuclear transcription factor has been proposed as a useful tool in the differential
diagnosis of small round cell sarcomas. Recently, FLI-1 has been reported as the first nuclear …

Purpose: Angiomatoid fibrous histiocytoma (AFH) is a low-grade mesenchymal neoplasm
which usually occurs in children and adolescents. Either FUS-ATF1 or EWSR1-ATF1 have …

Martin Hasselblatt· Inga Nagel· Florian Oyen· Kerstin Bartelheim· Robert B. Russell· Ulrich
Schüller· Reimar Junckerstorff· Marc Rosenblum· Ali H. Alassiri· Sabrina Rossi· Irene Schmid· …