Assessment of therapeutic tumor response using 99mTc-ethylenedicysteine-glucosamine

…, DF Yu, M Ito, CS Oh, S Kohanim… - Cancer biotherapy & …, 2004 - liebertpub.com
Purpose: The aim of this study was to evaluate 99m Tc-ethylenedicysteine-glucosamine (EC-DG)
for the assessment of tumor growth. Method: To evaluate whether 99mTc-EC-DG is …

Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors

…, M Cristofanilli, WD Erwin, DF Yu, S Kohanim… - Applied Radiation and …, 2008 - Elsevier
BACKGROUND: Early detection of cellular events is important to predict the outcome of the
patients. This study was aimed to use 99m Tc EC-annexin V to image tumor cells undergoing …

Regional Radiochemotherapy Using In Situ Hydrogel

…, DJ Yang, DF Yu, R Mendez, C Oh, S Kohanim… - Pharmaceutical …, 2005 - Springer
Purpose. To evaluate the feasibility of regional radiochemotherapy of mammary tumors
using in situ hydrogel loaded with cisplatin (CDDP) and rhenium-188 ( 188 Re). Methods. …

Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies

J Gong, D Yang, S Kohanim, R Humphreys… - Molecular Cancer …, 2006 - AACR
Susceptibility to apoptosis by tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)
is mediated through cognate death receptor signaling. We hypothesized that auto-…

Targeted functional imaging of estrogen receptors with 99mTc-GAP-EDL

N Takahashi, DJ Yang, S Kohanim, CS Oh… - European Journal of …, 2007 - Springer
Purpose To evaluate the feasibility of using 99m Tc-glutamate peptide-estradiol in functional
imaging of estrogen receptor-positive [ER(+)] diseases. Methods 3-Aminoethyl estradiol (…

99mTc-EC-Guanine: Synthesis, Biodistribution, and Tumor Imaging in Animals

…, T Yang, M Ito, A Greenwell, J Bryant, S Kohanim… - Pharmaceutical …, 2005 - Springer
Purpose DNA markers are useful in assessing cell proliferation. The purpose of this study
was to synthesize 99m Tc-ethylenedicysteine-guanine (EC-Guan) for evaluation of cell …

Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model

…, DJ Yang, H Kurihara, A Borne, S Kohanim… - Academic radiology, 2007 - Elsevier
RATIONALE AND OBJECTIVES: Endometriosis is a common women’s health problem.
Animal models provide an invaluable tool to study the natural history of endometriosis. We …

Synthesis of 99mTc-EC-AMT as an imaging probe for amino acid transporter systems in breast cancer

…, MS Ali, C Oh, R Mendez, S Kohanim… - Nuclear medicine …, 2010 - journals.lww.com
Objective This study was to develop a 99m Tc-labeled α-methyl tyrosine (AMT) using L, L-ethylenedicysteine
(EC) as a chelator and to evaluate its potential in breast tumor imaging in …

Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with 99mTc-DTPA-glipizide

CS Oh, S Kohanim, FL Kong, HC Song… - Annals of nuclear …, 2012 - Springer
Objective This study was aimed to assess pancreas beta cell activity using 99m Tc-diethyleneaminepentaacetic
acid-glipizide (DTPA-GLP), a sulfonylurea receptor agent. The effect of …

Molecular imaging of Bcr-Abl phosphokinase in a xenograft model

JY Wu, DJ Yang, LS Angelo, S Kohanim… - Molecular cancer …, 2009 - AACR
The purpose of this study was to determine whether the Bcr-Abl tyrosine kinase can be
assessed by γ-imaging using an 111 In-labeled anti-phosphotyrosine (APT) antibody, and if the …