The sulfonylurea receptor 1 (Sur1)-regulated NC Ca-ATP channel is a nonselective cation
channel that is regulated by intracellular calcium and adenosine triphosphate. The channel is …

Hypertonicity (most often present as high salinity) is stressful to the cells of virtually all
organisms. Cells survive in a hypertonic environment by increasing the transcription of genes …

Cell death proceeds by way of a variety of “cell death subroutines,” including several types
of “apoptosis,” “regulated necrosis,” and others. “Accidental necrosis” due to profound …

The mechanisms of heterolytic versus homolytic O−O bond cleavage of H 2 O 2 , tert-butyl
hydroperoxide (t-BuOOH), 2-methyl-1-phenyl-2-propyl hydroperoxide (MPPH), and m-…

The role of transient receptor potential M4 (Trpm4), an unusual member of the Trp family of
ion channels, is poorly understood. Using rodent models of spinal cord injury, we studied …

Subarachnoid hemorrhage (SAH) causes secondary brain injury due to vasospasm and
inflammation. Here, we studied a rat model of mild-to-moderate SAH intended to minimize …

Acute spinal cord injury (SCI) causes progressive hemorrhagic necrosis (PHN), a poorly
understood pathological process characterized by hemorrhage and necrosis that leads to …

Background Preclinical and emerging clinical data show that glibenclamide reduces space
occupying edema and brain swelling following cerebral ischemia. Glibenclamide is a potent …

While hyperosmolality of the kidney medulla is essential for urinary concentration, it
imposes a great deal of stress. Cells in the renal medulla adapt to the stress of hypertonicity (…

The sulfonylurea receptor 1 (Sur1)-NC Ca-ATP channel plays a central role in necrotic cell
death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain …