… GS Wu, TF Burns, ER McDonald 3rd, W Jiang, R Meng, ID Krantz, G Kao, DD Gan, JY
Zhou, R Muschel, SR Hamilton, NB Spinner, S Markowitz, G Wu, WS el-Deiry …

Background The stromal microenvironment and particularly the macrophage component of
primary tumors influence their malignant potential. However, at the metastatic site the role of …

Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC is …

Cancer stem cells (CSCs) are the subpopulation of cells within a tumor that can self-renew,
differentiate into multiple lineages, and drive tumor growth. Here we describe a two-pronged …

Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates
with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are …

The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

Purpose: Locoregional recurrence is the dominant form of treatment failure in head and neck
(H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently amplified in this …

Brain-specific homing and direct interactions with the neural substance are prominent
hypotheses for brain metastasis formation and a modern manifestation of Paget's “seed and soil” …

Tissue factor (TF) expression by tumor cells correlates with metastasis clinically and
supports metastasis in experimental settings. However, the precise pathways coupling TF to …

OBJECTIVE Mesenchymal stem cells (MSCs) are known to be capable of suppressing
immune responses, but the molecular mechanisms involved and the therapeutic potential of …