[HTML][HTML] Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi

E Dadachova, RA Bryan, X Huang, T Moadel… - PloS one, 2007 - journals.plos.org
Background Melanin pigments are ubiquitous in nature. Melanized microorganisms are often
the dominating species in certain extreme environments, such as soils contaminated with …

The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement

E Dadachova, RA Bryan, RC Howell… - Pigment cell & …, 2008 - Wiley Online Library
Melanized microorganisms are often found in environments with very high background radiation
levels such as in nuclear reactor cooling pools and the destroyed reactor in Chernobyl. …

Melanin is effective in protecting fast and slow growing fungi from various types of ionizing radiation

C Pacelli, RA Bryan, S Onofri… - Environmental …, 2017 - Wiley Online Library
Melanin is a ubiquitous pigment with unique physicochemical properties. The resistance of
melanized fungi to cosmic and terrestrial ionizing radiation suggests that melanin also plays …

[HTML][HTML] Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors

AD Schweitzer, RC Howell, Z Jiang, RA Bryan… - PloS one, 2009 - journals.plos.org
Background Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects
melanized microorganisms against high doses of ionizing radiation. However, the physics of …

The polysaccharide capsule of the pathogenic fungus Cryptococcus neoformans enlarges by distal growth and is rearranged during budding

O Zaragoza, A Telzak, RA Bryan… - Molecular …, 2006 - Wiley Online Library
The capsule of Cryptococcus neoformans can undergo dramatic enlargement, a phenomenon
associated with virulence. A prior study that used Ab to the capsule as a marker for older …

Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection

E Dadachova, A Nakouzi, RA Bryan… - Proceedings of the …, 2003 - National Acad Sciences
There is an urgent need for new antimicrobial therapies to combat drug resistance, new
pathogens, and the relative inefficacy of current therapy in compromised hosts. Ionizing radiation …

[HTML][HTML] Protection of Melanized Cryptococcus neoformans from Lethal Dose Gamma Irradiation Involves Changes in Melanin's Chemical Structure and …

A Khajo, RA Bryan, M Friedman, RM Burger… - PLoS …, 2011 - journals.plos.org
Protection of Melanized Cryptococcus neoformans from Lethal Dose Gamma Irradiation
Involves Changes in Melanin's Chemical Structure and Paramagnetism | PLOS ONE Skip to …

Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection

RA Bryan, Z Jiang, RC Howell… - The Journal of …, 2010 - academic.oup.com
Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus
neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/ Cr mice …

Compton scattering by internal shields based on melanin-containing mushrooms provides protection of gastrointestinal tract from ionizing radiation

…, RC Howell, AD Schweitzer, RA Bryan… - Cancer Biotherapy …, 2012 - liebertpub.com
There is a need for radioprotectors that protect normal tissues from ionizing radiation in patients
receiving high doses of radiation and during nuclear emergencies. We investigated the …

Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to γ-radiation versus radioimmunotherapy with α-and β-emitting …

E Dadachova, RW Howell, RA Bryan… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Bryan, Annie Frenkel, Joshua D. Nosanchuk and Arturo Casadevall … Dadachova E, Nakouzi
A, Bryan RA, Casadevall A. Ionizing radiation delivered by specific antibody is therapeutic …