Gliomas are uniformly fatal forms of primary brain neoplasms that vary from low- to high-grade
(glioblastoma). Whereas low-grade gliomas are weakly angiogenic, glioblastomas are …

… Russell C Rockne 1 … (C) Inferred biological event models can include alternative pathways
such as known germline mutations (eg VHL in patients with von Hippel-Lindau disease [40]). …

Chimeric antigen receptor T cell (CAR-T) therapy is an emerging strategy to improve
treatment outcomes for recurrent high-grade glioma, a cancer that responds poorly to current …

Purpose To demonstrate a method of generating patient-specific, biologically-guided
radiotherapy dose plans and compare them to the standard-of-care protocol. Methods and …

Glioblastoma multiforme (GBM) is a highly invasive primary brain tumour that has poor
prognosis despite aggressive treatment. A hallmark of these tumours is diffuse invasion into the …

Accurate clinical assessment of a patient's response to treatment for glioblastoma multiforme
(GBM), the most malignant type of primary brain tumor, is undermined by the wide patient-to…

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor associated
with a poor median survival of 15–18 months, yet there is wide heterogeneity across and …

BACKGROUND. Temozolomide (TMZ) is one of the most potent chemotherapy agents for
the treatment of glioblastoma. Unfortunately, almost half of glioblastoma tumors are TMZ …

Background Glioblastomas with a specific mutation in the isocitrate dehydrogenase 1 (IDH1)
gene have a better prognosis than gliomas with wild-type IDH1. Methods Here we compare …

Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126.
Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression …