Oncolytic vaccinia virus disrupts tumor-associated vasculature in humans

CJ Breitbach, R Arulanandam, N De Silva, SH Thorne… - Cancer research, 2013 - AACR
Efforts to selectively target and disrupt established tumor vasculature have largely failed to
date. We hypothesized that a vaccinia virus engineered to target cells with activation of the ras…

[HTML][HTML] Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity

…, A Alkayyal, J Zhang, F Le Boeuf, R Arulanandam… - Nature medicine, 2015 - nature.com
Tumors are complex ecosystems composed of networks of interacting 'normal' and malignant
cells. It is well recognized that cytokine-mediated cross-talk between normal stromal cells, …

Housekeeping genes; expression levels may change with density of cultured cells

…, R Honeywell, M Geletu, R Arulanandam… - Journal of …, 2010 - Elsevier
Western blotting is a powerful technique to characterize a multitude of cellular proteins. As
an internal control, the blots are commonly probed for “housekeeping” gene products. In this …

[HTML][HTML] Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine

…, DP Conrad, VA Tang, JS Diallo, R Arulanandam… - Molecular Therapy, 2012 - cell.com
Treatment of permissive tumors with the oncolytic virus (OV) VSV-Δ51 leads to a robust
antitumor T-cell response, which contributes to efficacy; however, many tumors are not …

[PDF][PDF] VEGF-mediated induction of PRD1-BF1/Blimp1 expression sensitizes tumor vasculature to oncolytic virus infection

R Arulanandam, C Batenchuk, FA Angarita… - Cancer Cell, 2015 - cell.com
Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor
vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia …

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

A Vultur, J Cao, R Arulanandam, J Turkson, R Jove… - Oncogene, 2004 - nature.com
Stat3 (signal transducer and activator of transcription-3) activity is required for transformation
by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to …

[HTML][HTML] Combination of Paclitaxel and MG1 oncolytic virus as a successful strategy for breast cancer treatment

…, DG Roy, A Pelin, AS Aitken, R Arulanandam… - Breast Cancer …, 2016 - Springer
Background Breast cancer is the most common malignant disease amongst Western women.
The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers …

The R (h) oads to Stat3: Stat3 activation by the Rho GTPases

L Raptis, R Arulanandam, M Geletu, J Turkson - Experimental cell research, 2011 - Elsevier
The signal transducer and activator of transcription-3 (Stat3) is a member of the STAT family
of cytoplasmic transcription factors. Overactivation of Stat3 is detected with high frequency in …

Antiviral potential of the antimicrobial drug atovaquone against SARS-CoV-2 and emerging variants of concern

ME Carter-Timofte, R Arulanandam… - ACS infectious …, 2021 - ACS Publications
The antimicrobial medication malarone (atovaquone/proguanil) is used as a fixed-dose
combination for treating children and adults with uncomplicated malaria or as chemoprophylaxis …

[HTML][HTML] Characterization of critical determinants of ACE2–SARS CoV-2 RBD interaction

…, H Yasavoli-Sharahi, Z Taha, R Arulanandam… - International Journal of …, 2021 - mdpi.com
Despite sequence similarity to SARS-CoV-1, SARS-CoV-2 has demonstrated greater
widespread virulence and unique challenges to researchers aiming to study its pathogenicity in …