User profiles for Roxana O. Carare

Roxana O Carare

Professor, Clinical Neuroanatomy, University of Southampton
Verified email at soton.ac.uk
Cited by 11388

Clearance systems in the brain—implications for Alzheimer disease

JM Tarasoff-Conway, RO Carare, RS Osorio… - Nature reviews …, 2015 - nature.com
Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and hyperphosphorylated
tau tangles—is the pathological hallmark of Alzheimer disease (AD). Aβ accumulation has …

Perivascular Drainage of Amyloid-β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

…, SD Preston, I Mazanti, RO Carare - Brain …, 2008 - search.ebscohost.com
Carare … From the results of the study by Carare et al. (15). … Carare RO, Bernardes-Silva
M, Newman TA, Page AM, Nicoll JAR, Perry VH, Weller RO (2008) Solutes, but not cells, drain …

Lymphatic drainage of the brain and the pathophysiology of neurological disease

RO Weller, E Djuanda, HY Yow, RO Carare - Acta neuropathologica, 2009 - Springer
There are no conventional lymphatics in the brain but physiological studies have revealed a
substantial and immunologically significant lymphatic drainage from brain to cervical lymph …

Vascular dysfunction—the disregarded partner of Alzheimer's disease

…, TJ Quinn, RN Kalaria, DJ Werring, RO Carare… - Alzheimer's & …, 2019 - Elsevier
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous
disease with multiple contributors to its pathophysiology, including vascular dysfunction…

[HTML][HTML] Lymphatic clearance of the brain: perivascular, paravascular and significance for neurodegenerative diseases

…, B Bedussi, AWJ Morris, RO Weller, RO Carare - Cellular and molecular …, 2016 - Springer
The lymphatic clearance pathways of the brain are different compared to the other organs of
the body and have been the subject of heated debates. Drainage of brain extracellular fluids…

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

…, R Schliebs, RO Weller, JA Nicoll, RO Carare - Acta …, 2011 - Springer
The deposition of amyloid-β (Aβ) peptides in the walls of leptomeningeal and cortical blood
vessels as cerebral amyloid angiopathy (CAA) is present in normal ageing and the majority …

[HTML][HTML] Vascular, glial, and lymphatic immune gateways of the central nervous system

B Engelhardt, RO Carare, I Bechmann, A Flügel… - Acta …, 2016 - Springer
Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma. …

[HTML][HTML] Vascular basement membranes as pathways for the passage of fluid into and out of the brain

…, CA Hawkes, A Verma, RO Weller, RO Carare - Acta …, 2016 - Springer
In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the
brain parenchyma to cervical lymph nodes is along basement membranes in the walls of …

Neurofilaments: neurobiological foundations for biomarker applications

AR Gafson, NR Barthélemy, P Bomont, RO Carare… - Brain, 2020 - academic.oup.com
Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

[HTML][HTML] Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

…, RO Weller, A Verma, CA Hawkes, RO Carare - Acta …, 2018 - Springer
Tracers injected into CSF pass into the brain alongside arteries and out again. This has
been recently termed the “glymphatic system” that proposes tracers enter the brain along …