[HTML][HTML] Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
RD Blumenthal, E Leon, HJ Hansen, DM Goldenberg - BMC cancer, 2007 - Springer
Background Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express
CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to …
CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to …
Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)
RD Blumenthal, HJ Hansen, DM Goldenberg - Cancer research, 2005 - AACR
CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with
adhesion and invasion. The effects of three monoclonal antibodies targeting different epitopes …
adhesion and invasion. The effects of three monoclonal antibodies targeting different epitopes …
Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines
C Waskewich, RD Blumenthal, H Li, R Stein… - Cancer research, 2002 - AACR
Cyclooxygenase-2 (COX-2) is an important cellular target for both therapy and/or prevention
of inflammatory disorders and cancer. The advent of selective COX-2 inhibitors now allows …
of inflammatory disorders and cancer. The advent of selective COX-2 inhibitors now allows …
Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives
TM Behr, RM Sharkey, ME Juweid, RD Blumenthal… - Cancer research, 1995 - AACR
The renal uptake of radiolabeled antibody fragments and peptides is a problem in
radioimmunodetection and radioimmunotherapy, especially with intracellularly retained radiometals. …
radioimmunodetection and radioimmunotherapy, especially with intracellularly retained radiometals. …
Methods and goals for the use of in vitro and in vivo chemosensitivity testing
RD Blumenthal, DM Goldenberg - Molecular biotechnology, 2007 - Springer
Sensitive, specific, and accurate methods to assay chemosensitivity are needed to (1) screen
new therapeutic agents, (2) identify patterns of chemosensitivity for different tumor types, (3…
new therapeutic agents, (2) identify patterns of chemosensitivity for different tumor types, (3…
Overcoming the nephrotoxicity of radiometal‐labeled immunoconjugates: improved cancer therapy administered to a nude mouse model in relation to the internal …
…, G Sgouros, RD Blumenthal… - … Journal of the …, 1997 - Wiley Online Library
BACKGROUND Elevated renal uptake and extended retention of radiolabeled antibody
fragments and peptides is a problem in the therapeutic application of such agents. However, …
fragments and peptides is a problem in the therapeutic application of such agents. However, …
[HTML][HTML] Potential of peroxisome proliferator-activated receptor gamma antagonist compounds as therapeutic agents for a wide range of cancer types
JD Burton, DM Goldenberg, RD Blumenthal - PPAR research, 2008 - hindawi.com
PPAR is a therapeutic target that has been exploited for treatment of type II diabetes mellitus
(T2DM) with agonist drugs. Since PPAR is expressed by many hematopoietic, mesodermal …
(T2DM) with agonist drugs. Since PPAR is expressed by many hematopoietic, mesodermal …
Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies
…, R Dunn, LC Swayne, GY Wong, RD Blumenthal… - Cancer Research, 1995 - AACR
A complementarity-determining region-grafted (humanized) version of MN-14 (hMN-14), a
high-affinity, anti-carcinoembryonic antigen (CEA) murine monoclonal antibody (mMAb), was …
high-affinity, anti-carcinoembryonic antigen (CEA) murine monoclonal antibody (mMAb), was …
Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22
…, LB Shih, HJ Hansen, RD Blumenthal… - Cancer Immunology …, 1997 - Springer
LL2 is an anti-CD22 pan-B-cell monoclonal antibody which, when radiolabeled, has a high
sensitivity for detecting B-cell, non-Hodgkin’s lymphoma (NHL), as well as an antitumor …
sensitivity for detecting B-cell, non-Hodgkin’s lymphoma (NHL), as well as an antitumor …
Degranulating eosinophils in human endometriosis
RD Blumenthal, M Samoszuk, AP Taylor… - The American journal of …, 2000 - Elsevier
Degranulating eosinophils have been described in most endometrial cancers. We hypothesized
that endometriosis (ectopic, nonneoplastic endometrial tissue) would be an appropriate …
that endometriosis (ectopic, nonneoplastic endometrial tissue) would be an appropriate …