A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been
identified in peripheral blood from cancer patients and are probably the origin of intractable …

Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically
similar tumours, monitor disease progress, and individualize treatment regimens 1 , 2 , …

Background The use of tyrosine kinase inhibitors to target the epidermal growth factor
receptor gene (EGFR) in patients with non–small-cell lung cancer is effective but limited by the …

Under laminar flow conditions, when no external forces are applied, particles are generally
thought to follow fluid streamlines. Contrary to this perspective, we observe that flowing …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis
thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 …

Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology
and a physiological rate of albumin secretion for at least 42 days. Hepatocytes cultured on …

Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay
in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 …

Background Over the past 20 years, there has been remarkable improvement in the chances
of survival of patients treated in burn centers. A simple, accurate system for objectively …