The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of
dopaminergic transmission at the D 2 receptor. We measured in vivo occupancy of striatal D 2 …

Background and Purpose—Secondary brain injury and edema formation contribute significantly
to morbidity and mortality after intracerebral hemorrhage (ICH). The pathogenesis of this …

Background: Recent brain imaging studies have indicated that schizophrenia is associated
with increased amphetamine-induced dopamine release in the striatum. It has long been …

Background Lower serotonergic activity correlates with high-lethality suicide attempts in major
depression. Postmortem studies of serotonin receptors in suicides localize changes to the …

BACKGROUND: Serotonin 1A receptors (5-HT 1A ) are implicated in the pathophysiology of
major depressive disorder (MDD) and in the action of selective serotonin reuptake inhibitors …

Background Regional cerebral blood flow (CBF), a good indirect index of cerebral pathologic
changes in Alzheimer disease (AD), is more severely reduced in patients with higher …

Radiopharmaceutical brain imaging is clinically applied in planning resective epilepsy
surgery. Cerebral sites of seizure generation-propagation are highly associated with regions of …

OBJECTIVE: CSF analysis, neuroendocrine challenges, serotonin depletion studies, and
treatment studies implicate the serotonergic system in the pathophysiology of major depressive …

OBJECTIVE: The authors examined effects of a triallelic functional polymorphism of the
human serotonin-transporter-linked promoter region (5-HTTLPR) on in vivo expression of …

Cognitive reserve (CR) is the ability of an individual to cope with advancing brain pathology
so that he remains free of symptomatology. Epidemiological evidence and in vivo …